| HGNC approved symbol | ELP5 |
| HGNC ID | HGNC:30617 |
| HGNC approved name | elongator acetyltransferase complex subunit 5 |
| Entrez gene ID | GeneID:23587
(SSTAR profile) |
| UniProt AC (human) | Q8TE02 |
| UniProt ID (human) | ELP5_HUMAN |
| Pfam domains | Elong_Iki1 PF10483 (11-181, 222-281) |
| MGI symbol | Elp5 |
| MGI ID | MGI:1859017 |
| UniProt AC (mouse) | Q99L85 |
| UniProt ID (mouse) | ELP5_MOUSE |
| HGNC gene family tag | ELP |
| HGNC gene family description | Elongator acetyltransferase complex subunits |
| Function | Histone modification write cofactor |
| Modification | Histone acetylation |
| PMID for information on function | PMID:11904415 |
| Protein complex | Pol2 elongator |
| Target molecule | histone |
| Target entity | H3K14, H4K8 |
| Product | # |
| PMID for information on target | PMID:11904415 |
| Comment | The elongating, hyperphosphorylated form of RNA polymerase II is associated with the Elongator complex, which has the histone acetyltransferase (HAT) Elp3 as a subunit. The three smallest Elongator subunits--Elp4, Elp5, and Elp6--are required for HAT activity, and Elongator binds to both naked and nucleosomal DNA. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. |
| Status of entry | # |