| HGNC approved symbol | L3MBTL1 |
| HGNC ID | HGNC:15905 |
| HGNC approved name | l(3)mbt-like 1 (Drosophila) |
| Entrez gene ID | GeneID:26013 (SSTAR profile) |
| UniProt AC (human) | Q9Y468 |
| UniProt ID (human) | LMBL1_HUMAN |
| Pfam domains | MBT PF02820 (310-377, 417-484, 521-586) zf-C2HC PF01530 (622-650) |
| MGI symbol | L3mbtl1 |
| MGI ID | MGI:2676663 |
| UniProt AC (mouse) | A2A5N8 |
| UniProt ID (mouse) | LMBL1_MOUSE |
| HGNC gene family tag | ZC2HC, SAMD |
| HGNC gene family description | Zinc fingers, C2HC-type containing, Sterile alpha motif (SAM) domain containing |
| Function | Histone modification read |
| Modification | # |
| PMID for information on function | PMID:18026117 |
| Protein complex | L3MBTL1 |
| Target molecule | histone |
| Target entity | H1BK26, H4K20 |
| Product | # |
| PMID for information on target | PMID:18026117 |
| Comment | Crystal structures of the L3MBTL1 MBT repeats in complex with histone H4 peptides dimethylated on Lys20 (H4K20me2). Only the second of the three MBT repeats can bind mono- and dimethylated histone peptides. Its binding pocket has similarities to that of 53BP1 and is able to recognize the degree of histone lysine methylation. |
| Status of entry | # |
| Expression range: | 0.0 to 30.37 |
| Mean expression: | 3.28 ± 3.54 |
| Median expression: | 2.29 |