| HGNC approved symbol | NCOA1 |
| HGNC ID | HGNC:7668 |
| HGNC approved name | nuclear receptor coactivator 1 |
| Entrez gene ID | GeneID:8648 (SSTAR profile) |
| UniProt AC (human) | Q15788 |
| UniProt ID (human) | NCOA1_HUMAN |
| Pfam domains | PAS PF00989 (116-176) PAS_11 PF14598 (259-368) NCOA_u2 PF16665 (437-682) SRC-1 PF08832 (630-699) Nuc_rec_co-act PF08815 (921-974) DUF1518 PF07469 (1142-1189, 1208-1268) |
| MGI symbol | Ncoa1 |
| MGI ID | MGI:1276523 |
| UniProt AC (mouse) | P70365 |
| UniProt ID (mouse) | NCOA1_MOUSE |
| HGNC gene family tag | KAT, bHLH |
| HGNC gene family description | Chromatin-modifying enzymes / K-acetyltransferases, Basic helix-loop-helix proteins |
| Function | Histone modification write |
| Modification | Histone acetylation |
| PMID for information on function | PMID:9296499 |
| Protein complex | # |
| Target molecule | histone |
| Target entity | H3, H4 |
| Product | # |
| PMID for information on target | PMID:9296499 |
| Comment | The HAT activity of SRC-1=NCOA1 maps to its carboxy-terminal region and is primarily specific for histones H3 and H4. Acetylation by SRC-1 and PCAF of histones bound at specific promoters may result from ligand binding to steroid receptors and could be a mechanism by which the activation functions of steroid receptors and associated coactivators enhance formation of a stable preinitiation complex, thereby increasing transcription of specific genes from transcriptionally repressed chromatin templates. |
| Status of entry | # |
| Expression range: | 0.0 to 66.11 |
| Mean expression: | 1.34 ± 3.52 |
| Median expression: | 0.48 |