| HGNC approved symbol | PRDM5 |
| HGNC ID | HGNC:9349 |
| HGNC approved name | PR domain containing 5 |
| Entrez gene ID | GeneID:11107 (SSTAR profile) |
| UniProt AC (human) | Q9NQX1 |
| UniProt ID (human) | PRDM5_HUMAN |
| Pfam domains | PRDM2_PR PF21549 (8-127) zf-C2H2 PF00096 (199-219, 262-287, 295-317, 320-342, 376-398, 404-426, 432-455, 489-511, 517-539, 545-567, 573-595, 602-625) zf-met PF12874 (234-254) zf-C2H2_6 PF13912 (348-370, 461-483) |
| MGI symbol | Prdm5 |
| MGI ID | MGI:1918029 |
| UniProt AC (mouse) | Q9CXE0 |
| UniProt ID (mouse) | PRDM5_MOUSE |
| HGNC gene family tag | ZNF |
| HGNC gene family description | Zinc fingers, C2H2-type |
| Function | Histone modification write |
| Modification | Histone methylation |
| PMID for information on function | PMID:23856557 |
| Protein complex | # |
| Target molecule | histone |
| Target entity | H3K9 |
| Product | H3K9me |
| PMID for information on target | PMID:23856557 |
| Comment | Some Prdms show intrinsic HKMTase activity (Prdm2, Prdm3, Prdm8, Prdm9, and Prdm16). In addition, Prdm1, Prdm5, and Prdm6 lack intrinsic HKMTase activity, but instead recruit G9a/Ehmt2/KMT1C, a strong mammalian histone H3 lysine 9 (H3K9) methyltransferase, to mediate HKMTase activity (see Fog et al., 2012 for a review). Another structural feature is that the Prdm family has multiple kruppel-type zinc finger (ZF) domains in the C-terminus involved in sequence-specific DNA binding and protein-protein interactions. |
| Status of entry | # |
| Expression range: | 0.0 to 16.89 |
| Mean expression: | 3.31 ± 3.05 |
| Median expression: | 2.81 |