| HGNC approved symbol | RAG1 |
| HGNC ID | HGNC:9831 |
| HGNC approved name | recombination activating gene 1 |
| Entrez gene ID | GeneID:5896 (SSTAR profile) |
| UniProt AC (human) | P15918 |
| UniProt ID (human) | RAG1_HUMAN |
| Pfam domains | RAG1_imp_bd PF12560 (1-291) zf-C3HC4 PF00097 (293-331) zf-RAG1 PF10426 (354-383) RAG1 PF12940 (387-1022) |
| MGI symbol | Rag1 |
| MGI ID | MGI:97848 |
| UniProt AC (mouse) | P15919 |
| UniProt ID (mouse) | RAG1_MOUSE |
| HGNC gene family tag | RNF |
| HGNC gene family description | RING-type (C3HC4) zinc fingers |
| Function | Histone modification write |
| Modification | Histone ubiquitination |
| PMID for information on function | PMID:21256161 |
| Protein complex | # |
| Target molecule | histone, DNA |
| Target entity | H3.3K, DNA motif |
| Product | H3.3Kub |
| PMID for information on target | PMID:21256161 |
| Comment | It has been suggested that RAG1 targets H3.3, the H3 variant known to be associated with recombining loci, and thus most likely to be encountered by RAG1 during V(D)J recombination. This reaction is absolutely dependent on an intact RAG1 RING domain, and requires regions of the far N-terminus of RAG1 where the H3.3 binding sight is likely to reside and regions within the H3 amino-terminal tail. Several H3.3 lysines are subject to ubiquitylation. |
| Status of entry | # |
| Expression range: | 0.0 to 2378.42 |
| Mean expression: | 5.5 ± 94.09 |
| Median expression: | 0.21 |