| HGNC approved symbol | RNF168 |
| HGNC ID | HGNC:26661 |
| HGNC approved name | ring finger protein 168, E3 ubiquitin protein ligase |
| Entrez gene ID | GeneID:165918
(SSTAR profile) |
| UniProt AC (human) | Q8IYW5 |
| UniProt ID (human) | RN168_HUMAN |
| Pfam domains | zf-C3HC4 PF00097 (16-55) |
| MGI symbol | Rnf168 |
| MGI ID | MGI:1917488 |
| UniProt AC (mouse) | Q80XJ2 |
| UniProt ID (mouse) | RN168_MOUSE |
| HGNC gene family tag | RNF |
| HGNC gene family description | RING-type (C3HC4) zinc fingers |
| Function | Histone modification write |
| Modification | Histone ubiquitination |
| PMID for information on function | PMID:22980979 |
| Protein complex | # |
| Target molecule | histone |
| Target entity | H2AK13, H2AK15, H2AXK13, H2AXK15 |
| Product | H2AK13ub, H2AK15ub, H2AXK13ub, H2AXK15ub |
| PMID for information on target | PMID:22980979 |
| Comment | RNF8 and RNF168 targets histone H2A and H2AX. RNF8 is the first ligase recruited to the damage site, and RNF168 follows RNF8-dependent ubiquitination. This suggests that RNF8 initiates H2A/H2AX ubiquitination with K63-linked ubiquitin chains and RNF168 extends them. RNF8 is inactive toward nucleosomal H2A, whereas RNF168 catalyzes the monoubiquitination of the histones specifically on K13-15. |
| Status of entry | # |