| HGNC approved symbol | RNF8 |
| HGNC ID | HGNC:10071 |
| HGNC approved name | ring finger protein 8, E3 ubiquitin protein ligase |
| Entrez gene ID | GeneID:9025 (SSTAR profile) |
| UniProt AC (human) | O76064 |
| UniProt ID (human) | RNF8_HUMAN |
| Pfam domains | FHA PF00498 (38-109) zf-C3HC4_3 PF13920 (400-446) |
| MGI symbol | Rnf8 |
| MGI ID | MGI:1929069 |
| UniProt AC (mouse) | Q8VC56 |
| UniProt ID (mouse) | RNF8_MOUSE |
| HGNC gene family tag | RNF |
| HGNC gene family description | RING-type (C3HC4) zinc fingers |
| Function | Histone modification write |
| Modification | Histone ubiquitination |
| PMID for information on function | PMID:22980979 |
| Protein complex | # |
| Target molecule | histone |
| Target entity | H2AK63, H2AXK63, H2AK48, H2AXK48 |
| Product | H2AK63ub, H2AXK63ub, H2AK48ub, H2AXK48ub |
| PMID for information on target | PMID:22980979 |
| Comment | Ubiquitin-dependent signaling during the DNA damage response (DDR) to double-strand breaks (DSBs) is initiated by two E3 ligases, RNF8 and RNF168, targeting histone H2A and H2AX. RNF8 is the first ligase recruited to the damage site, and RNF168 follows RNF8-dependent ubiquitination. This suggests that RNF8 initiates H2A/H2AX ubiquitination with K63-linked ubiquitin chains and RNF168 extends them. |
| Status of entry | # |
| Expression range: | 0.0 to 104.3 |
| Mean expression: | 17.0 ± 9.12 |
| Median expression: | 16.1 |