| HGNC approved symbol | SSRP1 |
| HGNC ID | HGNC:11327 |
| HGNC approved name | structure specific recognition protein 1 |
| Entrez gene ID | GeneID:6749 (SSTAR profile) |
| UniProt AC (human) | Q08945 |
| UniProt ID (human) | SSRP1_HUMAN |
| Pfam domains | POB3_N PF17292 (3-96) SSrecog PF03531 (105-170) PH1_SSRP1-like PF21103 (197-327) Rttp106-like_middle PF08512 (340-427) HMG_box PF00505 (547-615) SSRP1_C PF21092 (663-709) |
| MGI symbol | Ssrp1 |
| MGI ID | MGI:107912 |
| UniProt AC (mouse) | Q08943 |
| UniProt ID (mouse) | SSRP1_MOUSE |
| HGNC gene family tag | # |
| HGNC gene family description | # |
| Function | Chromatin remodeling |
| Modification | # |
| PMID for information on function | PMID:12934006 |
| Protein complex | FACT |
| Target molecule | histone |
| Target entity | H3, H4 |
| Product | # |
| PMID for information on target | PMID:12934006 |
| Comment | Both FACT and Spt16 can bind to nucleosomes and H2A-H2B dimers, whereas SSRP1 can only bind to H3-H4 tetramers but not to intact nucleosomes. Possibly, upon FACT binding to the nucleosome in the transcribed region, Spt16 facilitates the H2A-H2B displacement, which promotes the interaction between SSRP1 and the “altered” nucleosome. |
| Status of entry | # |
| Expression range: | 0.0 to 164.73 |
| Mean expression: | 48.94 ± 27.1 |
| Median expression: | 43.71 |