| HGNC approved symbol | TDRKH |
| HGNC ID | HGNC:11713 |
| HGNC approved name | tudor and KH domain containing |
| Entrez gene ID | GeneID:11022 (SSTAR profile) |
| UniProt AC (human) | Q9Y2W6 |
| UniProt ID (human) | TDRKH_HUMAN |
| Pfam domains | KH_1 PF00013 (54-116, 126-190) TUDOR PF00567 (305-423) |
| MGI symbol | Tdrkh |
| MGI ID | MGI:1919884 |
| UniProt AC (mouse) | Q80VL1 |
| UniProt ID (mouse) | TDRKH_MOUSE |
| HGNC gene family tag | TDRD |
| HGNC gene family description | Tudor domain containing |
| Function | RNA modification |
| Modification | # |
| PMID for information on function | PMID:23714778 |
| Protein complex | # |
| Target molecule | RNA |
| Target entity | piRNA |
| Product | # |
| PMID for information on target | PMID:23714778 |
| Comment | Piwi proteins and Piwi-interacting RNAs (piRNAs) repress transposition, regulate translation, and guide epigenetic programming in the germline. The evolutionarily conserved Tudor and KH domain-containing protein, Tdrkh (a.k.a. Tdrd2), is required for spermatogenesis and involved in piRNA biogenesis, the primary piRNA biogenesis pathway involves 3'→5' processing of 31-37 nt intermediates and that Tdrkh promotes this final step of piRNA biogenesis but not the ping-pong cycle. |
| Status of entry | # |
| Expression range: | 0.0 to 37.51 |
| Mean expression: | 4.95 ± 5.04 |
| Median expression: | 3.44 |