| HGNC approved symbol | UTY |
| HGNC ID | HGNC:12638 |
| HGNC approved name | ubiquitously transcribed tetratricopeptide repeat containing, Y-linked |
| Entrez gene ID | GeneID:7404 (SSTAR profile) |
| UniProt AC (human) | O14607 |
| UniProt ID (human) | UTY_HUMAN |
| Pfam domains | TPR_8 PF13181 (202-235) JmjC PF02373 (1080-1188) KDM6_C-hel PF21322 (1195-1249) KDM6_GATAL PF21326 (1267-1327) |
| MGI symbol | Uty |
| MGI ID | MGI:894810 |
| UniProt AC (mouse) | P79457 |
| UniProt ID (mouse) | UTY_MOUSE |
| HGNC gene family tag | TTC |
| HGNC gene family description | Tetratricopeptide (TTC) repeat domain containing |
| Function | Histone modification erase |
| Modification | Histone ubiquitination |
| PMID for information on function | PMID:24798337 |
| Protein complex | # |
| Target molecule | histone |
| Target entity | H3K27me |
| Product | # |
| PMID for information on target | PMID:24798337 |
| Comment | The Jumonji C lysine demethylases (KDMs) are 2-oxoglutarate- and Fe(II)-dependent oxygenases. KDM6A (UTX) and KDM6B (JMJD3) are KDM6 subfamily members that catalyze demethylation of Nϵ-methylated histone 3 lysine 27 (H3K27), a mark important for transcriptional repression. Despite reports stating that UTY (KDM6C) is inactive as a KDM, we demonstrate by biochemical studies, employing MS and NMR, that UTY (KDM6C) is an active KDM. Crystallographic analyses reveal that the UTY(KDM6C) active site is highly conserved with those of KDM6B and KDM6A. |
| Status of entry | # |
| Expression range: | 0.0 to 147.55 |
| Mean expression: | 11.49 ± 22.63 |
| Median expression: | 0.0 |