HGNC approved symbol | HOTAIR |
HGNC ID | HGNC:33510 |
Alternative names | HOXC-AS4, HOXC11-AS1, NCRNA00072 |
HGNC approved name | HOX transcript antisense RNA |
Entrez gene ID | GeneID:100124700 (SSTAR profile) |
HGNC gene family tag | # |
HGNC gene family description | Long non-coding RNAs with non-systematic symbols |
Function | Histone modifier recruitment |
PMID for reference on function | PMID:29685978, PMID:31901481 |
Target molecule type | Protein |
Specific target | EZH2 |
Target UniProt ID | EZH2_HUMAN |
PMID for reference on targets and products | PMID:29685978, PMID:31901481 |
Comment | Recruits EZH2 to silence E-Cadherin expression, thereby promoting cell migration and invasion. Represses tumor suppressor gene expression by hypermethylation of its CpG island. |
Status of entry | New |