| HGNC approved symbol | MAGI2-AS3 |
| HGNC ID | HGNC:40862 |
| Alternative names | ENST00000414797 |
| HGNC approved name | MAGI2 antisense RNA 3 |
| Entrez gene ID | GeneID:100505881
(SSTAR profile) |
| HGNC gene family tag | # |
| HGNC gene family description | Antisense RNAs |
| Function | Histone modifier recruitment, miRNA sponging |
| PMID for reference on function | PMID:33231563, PMID:32138716, PMID:32681706, PMID:31709544, PMID:31910343, PMID:31837602, PMID:30883342, PMID:31629962 |
| Target molecule type | RNA, Protein |
| Specific target | miR-31-5p, miR-25, miR-525-5p, miR-3163, miR-155, miR-141/200a, miR-374a, KDM1A |
| Target UniProt ID | KDM1A_HUMAN |
| PMID for reference on targets and products | PMID:33231563, PMID:32138716, PMID:32681706, PMID:31709544, PMID:31910343, PMID:31837602, PMID:30883342, PMID:31629962 |
| Comment | Acts as molecular sponge of miR-31-5p, miR-25, miR-525-5p, miR-3163, miR-155, miR-141/200a, miR-374a. MAGI2-AS3 plays an important role as a tumour suppressor by targeting Fas and FasL signalling. lncRNA MAGI2‑AS3 promotes expression of Fas and FasL in breast cancer cells. Recruits KDM1A to H3K4me2 deDNA Methylation at the RACGAP1 promoter, which ultimately decreased the expression of RACGAP1. |
| Status of entry | New |