| HGNC approved symbol | MEG3 |
| HGNC ID | HGNC:14575 |
| Alternative names | GTL2, NCRNA00023, LINC00023, onco-lncRNA-83 |
| HGNC approved name | maternally expressed 3 |
| Entrez gene ID | GeneID:55384
(SSTAR profile) |
| HGNC gene family tag | # |
| HGNC gene family description | Long non-coding RNAs with non-systematic symbols |
| Function | Histone modifier recruitment, Splicing factor recruitment, TF recruitment, miRNA sponging, DNA modifier recruitment |
| PMID for reference on function | PMID:30793226, PMID:30887511, PMID:31863691, PMID:31328388, 29024030, PMID:33284093, PMID:31790140, PMID:32420340, PMID:30476192, PMID:33180644 |
| Target molecule type | DNA, RNA, Protein |
| Specific target | PTBP3, EZH2, DNMT1, KLF4, miR-421 miR-135, miR-147, miR-6088, miR-223 |
| Target UniProt ID | PTBP3_HUMAN, EZH2_HUMAN, DNMT1_HUMAN, KLF4_HUMAN |
| PMID for reference on targets and products | PMID:30793226, PMID:30887511, PMID:31863691, PMID:31328388, 29024030, PMID:33284093, PMID:31790140, PMID:32420340, PMID:30476192, PMID:33180644 |
| Comment | Act as molecular sponge of miR-421 miR-135, miR-147, miR-6088, miR-223. Boosts the expression and maturation of miR122 which is decreased PKM2 levels and therefore suppressed expression of cyclin D1 and C-Myc. Negatively regulates miR-664 expression resulting in increased ADH4. GA-rich motifs able to direct MEG3 to its target genes PRC2 and H3K27me3 and regulate TGF-β pathway genes. In association with DNMT1 controls endotgelial-mesenchymal transition in diabetic retinopathy. Facilitates H3K27 trimethylation of EN2 through binding to EZH2. Interacts with PTBP3 to regulate gene expression and endothelial function through p53 signaling. Binds KLF4 and inhibited its protein expression. |
| Status of entry | New |