HGNC approved symbol HGNC ID HGNC approved name Entrez gene ID UniProt AC (human)
UniProt ID (human)
Pfam domains MGI symbol MGI ID UniProt AC (mouse)
UniProt ID (mouse)
HGNC gene family tag HGNC gene family description Function Modification PMID for information on function Protein complex Target molecule Target entity Product PMID for information on target Comment Status of entry
ACTB
(details) 		132 actin, beta 60 P60709 ACTB_HUMAN Actin PF00022 4-375 Actb 87904 P60710 ACTB_MOUSE # # Chromatin remodeling cofactor # 10966108 BAF, nBAF, npBAF, PBAF, SWI/SNF-like EPAFB, bBAF, SWI/SNF BRM-BRG1, NuA4, NuA4-related complex chromatin # # 10966108 β-actin=ACTB and actin-related proteins appear to have weak ATPase activities, which contribute ∼1% of the total activity in the BAF remodeling complex (Zhao et al. 1998). Results of experiments using the actin monomer sequestering product latrunculin B suggest that β-actin and BAF53 are required for stimulation of the ATPase activity of the BAF complex by chromatin #
ACTL6A
(details) 		24124 actin-like 6A 86 O96019 ACL6A_HUMAN Actin PF00022 10-428 Actl6a 1861453 Q9Z2N8 ACL6A_MOUSE INO80 INO80 complex subunits Chromatin remodeling cofactor # 9845365 BAF, npBAF, PBAF, SWI/SNF_Brg1(I), SWI/SNF_Brg1(II), SWI/SNF_Brm, SWI/SNF-like_EPAFa, WINAC, SWI/SNF-like EPAFB, SWI/SNF BRM-BRG1, Ino80, NuA4, NuA4-related complex, SRCAP chromatin # # 9845365 β-actin and BAF53 =ACTL6A are required for maximal ATPase activity of BRG1 and are also required with BRG1 for association of the complex with chromatin/matrix. #
ACTL6B
(details) 		160 actin-like 6B 51412 O94805 ACL6B_HUMAN Actin PF00022 9-425 Actl6b 1933548 Q99MR0 ACL6B_MOUSE # # Chromatin remodeling cofactor # 11726552 BAF, nBAF, PBAF, SWI/SNF_Brg1(I), SWI/SNF_Brg1(II), SWI/SNF_Brm, SWI/SNF BRM-BRG1 chromatin # # 11726552 Belongs to the chromatin remodeling brain-specific BAF (bBAF) complex, as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion. #
APOBEC1
(details) 		604 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 339 P41238 ABEC1_HUMAN APOBEC4_like PF18774 27-158 Apobec1 103298 P51908 ABEC1_MOUSE APOBEC Apolipoprotein B mRNA editing enzymes DNA modification, RNA modification DNA demethylation, mRNA editing 22001110 APOB_mRNA_editosome DNA, RNA ssDNA, mRNA, mC U 22001110 Fig. A2 in the reference (APOBEC1 or A1 has no known mammalian DNA substrate but it has DNA deaminase activity sufficient to induce reversion mutations when overexpressed in E. coli. In addition, A1 expressed in neurons may have a protective function against HSV (Herpers simplex virus) that involves ssDNA deamination of the viral genome). #
APOBEC2
(details) 		605 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 10930 Q9Y235 ABEC2_HUMAN APOBEC2 PF18772 47-223 Apobec2 1343178 Q9WV35 ABEC2_MOUSE APOBEC Apolipoprotein B mRNA editing enzymes DNA modification, RNA modification DNA demethylation, mRNA editing 21496894, 22001110 # DNA, RNA ssDNA, mRNA, mC hmU 22001110, 21496894 Fig. A2 in the reference #
APOBEC3A
(details) 		17343 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A 200315 P31941 ABC3A_HUMAN NAD2 PF18782 13-195 # # # # APOBEC Apolipoprotein B mRNA editing enzymes DNA modification, RNA modification DNA demethylation, mRNA editing 22001110 # DNA, RNA ssDNA, mRNA, mC dhU 22001110 Fig. A2 in the reference (Targets are exogenous retroviruses ssDNA like HIV, DNA viruses or transposable elements/ endogenous retroelements e.g. LINEs, SINEs and LTR). #
APOBEC3B
(details) 		17352 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B 9582 Q9UH17 ABC3B_HUMAN NAD2 PF18782 8-190 193-379 Apobec3 1933111 Q99J72 ABEC3_MOUSE APOBEC Apolipoprotein B mRNA editing enzymes DNA modification, RNA modification DNA demethylation, mRNA editing 22001110 # DNA, RNA ssDNA, mRNA, mC dhU 22001110 Fig. A2 in the reference (Targets are DNA viruses or transposable elements/ endogenous retroelements e.g. LINEs, SINEs and LTR). #
APOBEC3C
(details) 		17353 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C 27350 Q9NRW3 ABC3C_HUMAN NAD2 PF18782 11-189 # # # # APOBEC Apolipoprotein B mRNA editing enzymes DNA modification, RNA modification DNA demethylation, mRNA editing 22001110 # DNA, RNA ssDNA, mRNA, mC dhU 22001110 Fig. A2 in the reference (Targets are transposable elements/ endogenous retroelements e.g. LINEs, SINEs and LTR). #
APOBEC3D
(details) 		17354 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D 140564 Q96AK3 ABC3D_HUMAN NAD2 PF18782 10-202 207-381 # # # # APOBEC Apolipoprotein B mRNA editing enzymes DNA modification, RNA modification DNA demethylation, mRNA editing 21835787 # DNA, RNA ssDNA, mRNA, mC dhU 22001110 Fig. A2 in the reference (Targets are exogenous retroviruses ssDNA like HIV or transposable elements/ endogenous retroelements e.g. LINEs and SINEs). #
APOBEC3F
(details) 		17356 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F 200316 Q8IUX4 ABC3F_HUMAN NAD2 PF18782 4-190 192-372 # # # # APOBEC Apolipoprotein B mRNA editing enzymes DNA modification, RNA modification DNA demethylation, mRNA editing 22001110 APOB_mRNA_editosome DNA, RNA ssDNA, mRNA, mC dhU 22001110 Fig. A2 in the reference (Targets are exogenous retroviruses ssDNA like HIV, DNA viruses or transposable elements/ endogenous retroelements e.g. LINEs, SINEs and LTR). #
APOBEC3G
(details) 		17357 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G 60489 Q9HC16 ABC3G_HUMAN NAD2 PF18782 8-190 200-381 # # # # APOBEC Apolipoprotein B mRNA editing enzymes DNA modification, RNA modification DNA demethylation, mRNA editing 22001110 APOB_mRNA_editosome DNA, RNA ssDNA, mRNA, mC dhU 22001110 Fig. A2 in the reference (Targets are exogenous retroviruses ssDNA like HIV, DNA viruses or transposable elements/ endogenous retroelements e.g. SINEs and LTR). #
APOBEC3H
(details) 		24100 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H 164668 Q6NTF7 ABC3H_HUMAN APOBEC3 PF18771 25-157 # # # # APOBEC Apolipoprotein B mRNA editing enzymes DNA modification, RNA modification DNA demethylation, mRNA editing 22001110 APOB_mRNA_editosome DNA, RNA ssDNA, mRNA, mC dhU 22001110 Fig. A2 in the reference (Targets are exogenous retroviruses ssDNA like HIV or transposable elements/ endogenous retroelements e.g. LINEs, SINEs and LTR). #
ARID1A
(details) 		11110 AT rich interactive domain 1A (SWI-like) 8289 O14497 ARI1A_HUMAN ARID PF01388 1018-1104, BAF250_C PF12031 1970-2222 Arid1a 1935147 A2BH40 ARI1A_MOUSE ARID # Chromatin remodeling cofactor # 18448678 BAF, nBAF, npBAF, PBAF, SWI/SNF_Brg1(I), SWI/SNF_Brg1(II), SWI/SNF_Brm, WINAC, bBAF, SWI/SNF BRM-BRG1 DNA DNA motif # 18448678 BAF250a=ARID1A mediated chromatin remodeling plays a critical role in maintaining a particular chromatin configuration of its target genes that is essential for ES pluripotency and mesoderm formation. #
ARID1B
(details) 		18040 AT rich interactive domain 1B (SWI1-like) 57492 Q8NFD5 ARI1B_HUMAN ARID PF01388 1137-1223, BAF250_C PF12031 2006-2266 Arid1b 1926129 # # ARID # Histone modification write Histone ubiquitination 20086098 BAF, nBAF, npBAF, PBAF, SWI/SNF-like_EPAFa, SWI/SNF-like EPAFB, SWI/SNF BRM-BRG1 histone, DNA H2BK120, DNA motif # 20086098 The characteristic member of human SWI/SNF-A is BAF250/ARID1, of which there are two isoforms, BAF250a/ARID1a and BAF250b/ARID1b. The immunopurified BAF250b E3 ubiquitin ligase was found to target histone H2B at lysine 120 for monoubiquitination in vitro. #
ARID2
(details) 		18037 AT rich interactive domain 2 (ARID, RFX-like) 196528 Q68CP9 ARID2_HUMAN ARID PF01388 17-101, RFX_DNA_binding PF02257 524-602 Arid2 1924294 # # ARID # Chromatin remodeling cofactor # 15640446 PBAF DNA DNA motif # 15640446 Extends the role of ARID-containing subunits as components of SWI/SNF-related chromatin-remodeling complexes. Analysis of ARID2 in the DNA pull-down assay (Figure 4) indicates that it binds DNA without sequence specificity, like all other known ARID-containing components of SWI/SNF-related complexes. #
ARID4A
(details) 		9885 AT rich interactive domain 4A (RBP1-like) 5926 P29374 ARI4A_HUMAN RBB1NT PF08169 171-268, ARID PF01388 311-397, Tudor-knot PF11717 577-631 Arid4a 2444354 # # ARID # Histone modification write cofactor Histone acetylation 15640446 mSin3A DNA DNA motif # 15640446 ARID4 subfamily DNA-binding activity is represented here by RBP1 (ARID4A). Amino acid identity within the ARID consensus is 75% between RBP1 (ARID4A) and RBP1L1 (ARID4B), the only other member of this class. Both RBP1 and RBP1L1/SAP180 have been found in association with the mSIN3-histone deacetylase complex. #
ARID4B
(details) 		15550 AT rich interactive domain 4B (RBP1-like) 51742 Q4LE39 ARI4B_HUMAN RBB1NT PF08169 169-263, ARID PF01388 308-394, Tudor-knot PF11717 572-626 Arid4b 2137512 A2CG63 ARI4B_MOUSE ARID # Histone modification write cofactor Histone acetylation 15640446 mSin3A DNA DNA motif # 15640446 ARID4 subfamily DNA-binding activity is represented here by RBP1 (ARID4A). Amino acid identity within the ARID consensus is 75% between RBP1 (ARID4A) and RBP1L1 (ARID4B), the only other member of this class. Both RBP1 and RBP1L1/SAP180 have been found in association with the mSIN3-histone deacetylase complex. #
ARNTL
(details) 		701 aryl hydrocarbon receptor nuclear translocator-like 406 O00327 BMAL1_HUMAN HLH PF00010 74-126, PAS PF00989 149-254, PAS_11 PF14598 339-442 Arntl 1096381 Q9WTL8 BMAL1_MOUSE bHLH Basic helix-loop-helix proteins Histone modification write cofactor, TF TF activator 14645221, 24395244 # histone # # 14645221, 24395244 The coincidence of a rhythm in histone H3 and histone H4 acetylation on the proximal E-box of hPer1 with transcriptional activation of per1 and per2 is consistent with the heterodimeric complexes of CLOCK, NPAS2 and BMAL1 = ARNTL recruiting a histone acetyltransferase (HAT)-containing transcriptional co-activation complex to achieve maximal target gene activation; CLOCK:BMAL1 functions like pioneer transcription factors and regulates the DNA accessibility of other transcription factors. #
ASH1L
(details) 		19088 ash1 (absent, small, or homeotic)-like (Drosophila) 55870 Q9NR48 ASH1L_HUMAN AWS PF17907 2105-2142, SET PF00856 2156-2261, Bromodomain PF00439 2462-2533, PHD_5 PF20826 2586-2628, BAH PF01426 2662-2798 Ash1l 2183158 Q99MY8 ASH1L_MOUSE KMT, PHF Chromatin-modifying enzymes / K-methyltransferases, Zinc fingers, PHD-type Histone modification write Histone methylation 21239497 # histone H3K36 H3K36me 21239497 Human ASH1L specifically methylates histone H3 Lys-36. Implicates that there may be a regulatory mechanism of ASH1L histone methyltransferases. #
ASH2L
(details) 		744 ash2 (absent, small, or homeotic)-like (Drosophila) 9070 Q9UBL3 ASH2L_HUMAN PHD_ash2p_like PF21257 105-159, ASH2L-like_WH PF21198 161-266, SPRY PF00622 421-494 Ash2l 1344416 Q91X20 ASH2L_MOUSE PHF Zinc fingers, PHD-type Histone modification write cofactor Histone methylation 21285357 COMPASS, Menin-associated_HMT, MLL-HCF, CHD8, MLL2/3, COMPASS-like MLL1,2, MLL4/WBP7, COMPASS-like MLL3,4 histone # # 21285357 The oncoprotein Ash2L is a component of the mixed lineage leukemia (MLL) family members 1–4, Setd1A, and Setd1B mammalian histone H3K4 methyltransferase complexes and is essential to maintain global trimethylation of histone H3K4. #
ASXL1
(details) 		18318 additional sex combs like transcriptional regulator 1 171023 Q8IXJ9 ASXL1_HUMAN HARE-HTH PF05066 11-82, ASXH PF13919 244-363, PHD_3 PF13922 1502-1539 Asxl1 2684063 P59598 ASXL1_MOUSE # # Histone modification erase, Polycomb group (PcG) protein Histone deubiquitination 20436459 PR-DUB histone H2AK119 H2AK119ub1 20436459 Reconstituted recombinant Drosophila and human PR-DUB=ASXL1 complexes remove monoubiquitin from H2A but not from H2B in nucleosomes. #
ASXL2
(details) 		23805 additional sex combs like transcriptional regulator 2 55252 Q76L83 ASXL2_HUMAN HARE-HTH PF05066 11-84, ASXH PF13919 266-381, PHD_3 PF13922 1376-1433 Asxl2 1922552 Q8BZ32 ASXL2_MOUSE # # Histone modification read # 21047783 # histone H3K4, H3K9 # 21047783 ASXL2 occupies the aP2 promoter together with histone-lysine N-methyltransferase MLL1 and Lys-9-acetylated and Lys-4-methylated H3 histones. Microarray analysis demonstrated that ASXL1 represses, whereas ASXL2 increases, the expression of adipogenic genes. #
ASXL3
(details) 		29357 additional sex combs like transcriptional regulator 3 80816 Q9C0F0 ASXL3_HUMAN HARE-HTH PF05066 11-82, ASXH PF13919 241-361, PHD_3 PF13922 2204-2246 Asxl3 2685175 Q8C4A5 ASXL3_MOUSE # # Scaffold protein, Polycomb group (PcG) protein # 23736028 # histone # # 23736028 ASXL family members are epigenetic scaffolding proteins that assemble epigenetic regulators and transcription factors to specific genomic loci with histone modifications, contain PHD domain. #
ATXN7L3
(details) 		25416 ataxin 7-like 3 56970 Q14CW9 AT7L3_HUMAN Sgf11 PF08209 81-112, SCA7 PF08313 207-237 Atxn7l3 3036270 A2AWT3 AT7L3_MOUSE # # Histone modification erase cofactor Histone deubiquitination 18206972 SAGA histone # # 18206972 ATXN7L3, USP22, and ENY2 are the human orthologs of yeast Sgf11, Ubp8, and Sus1, respectively, and they are integral components of TFTC/STAGA complex. These three proteins together form a module of the TFTC/STAGA complex, which specifically removes the ubiquitin moiety from monoubiquitinated histones H2A and H2B. #
AURKC
(details) 		11391 aurora kinase C 6795 Q9UQB9 AURKC_HUMAN Pkinase PF00069 43-293 Aurkc 1321119 O88445 AURKC_MOUSE # # Histone modification write Histone phosphorylation 15499654 # histone H3S10, H3S28 # 15499654 Aurora-C=AURKC, like Aurora-B kinase, is a chromosomal passenger protein localizing first to centromeres and then to the midzone of mitotic cells. Aurora-C transcript is expressed at a moderate level albeit about an order of magnitude lower than Aurora-B transcript in diploid human fibroblasts. #
BARD1
(details) 		952 BRCA1 associated RING domain 1 580 Q99728 BARD1_HUMAN zf-RING_6 PF14835 42-107, Ank_2 PF12796 428-523, BRCT PF00533 569-643 Bard1 1328361 O70445 BARD1_MOUSE ANKRD Ankyrin repeat domain containing Histone modification write Histone ubiquitination 19916563 BRCC, BRCA1-A histone H2AX, H2A, H2B, H3, H4 H2AXub, H2Aub, H2Bub, H3ub, H4ub 19916563, 12485996 BARD1, like CstF-50, also interacts with RNA polymerase II. BARD1-mediated inhibition of polyadenylation may prevent inappropriate RNA processing during transcription, #
BCORL1
(details) 		25657 BCL6 corepressor-like 1 63035 Q5H9F3 BCORL_HUMAN Ank_2 PF12796 1500-1591, PUFD PF16553 1668-1782 Bcorl1 2443910 A2AQH4 BCORL_MOUSE ANKRD Ankyrin repeat domain containing Histone modification erase cofactor Histone deacetylation 23523425, 17379597 BCOR histone H3K36me2 # 23523425 Homologous to BCOR; which is a component of a complex (dRAF-like complex) in companion with KDM2B, a H3K36me2 demethylase. #
BMI1
(details) 		1066 BMI1 proto-oncogene, polycomb ring finger 648 P35226 BMI1_HUMAN zf-C3HC4_2 PF13923 18-56, RAWUL PF16207 162-226 Bmi1 88174 P25916 BMI1_MOUSE RNF, PCGF RING-type (C3HC4) zinc fingers, Polycomb group ring fingers Polycomb group (PcG) protein # 15386022 PRC1 # # # 15386022 The complex, termed hPRC1L (human Polycomb repressive complex 1-like), is composed of several Polycomb-group proteins including Ring1, Ring2, Bmi1 and HPH2. #
BRMS1L
(details) 		20512 breast cancer metastasis-suppressor 1-like 84312 Q5PSV4 BRM1L_HUMAN Sds3 PF08598 62-184 Brms1l 1196337 Q3U1T3 BRM1L_MOUSE # # Histone modification erase Histone deacetylation 15451426 mSin3A histone # # 15451426 p40-associated Sin3A/HDAC1 complex can deacetylate histone peptides in vitro. p40 can also repress transcription when tethered to the Gal-regulated promoter by the Gal-DNA binding domain. #
C11orf30
(details) 		18071 chromosome 11 open reading frame 30 56946 Q7Z589 EMSY_HUMAN ENT PF03735 16-84 2210018M11Rik 1924203 Q8BMB0 EMSY_MOUSE # # Histone modification write cofactor Histone methylation 19131338 # histone # # # Part of a complex with histone methyltranferase activity. UniProt: Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. #
C17orf49
(details) 		28737 chromosome 17 open reading frame 49 124944 Q8IXM2 BAP18_HUMAN 0610010K14Rik 1915609 Q9DCT6 BAP18_MOUSE # # Histone modification read # 20850016 CHD8, MLL2/3, MLL4/WBP7 histone H3K4me3 # 20850016 H3K4me3 readers Sgf29, TRRAP, PHF8, GATAD1, and BAP18=C17orf49, are associated mainly with promoters (Figures S3A and S3B) and coincide with H3K4me3 marking. #
CBLL1
(details) 		21225 E3 ubiquitin-protein ligase Hakai (EC 2.3.2.27) (Casitas B-lineage lymphoma-transforming sequence-like protein 1) (c-Cbl-like protein 1) (RING finger protein 188) (RING-type E3 ubiquitin transferase Hakai) 79872 Q75N03 HAKAI_HUMAN zf_Hakai PF18408 161-191 Cbll1 2144842 Q9JIY2 HAKAI_MOUSE RNF Ring finger proteins RNA modification RNA methylation 29507755 WMM RNA A of mRNA m6A 29507755 # New
CDYL
(details) 		1811 chromodomain protein, Y-like 9425 Q9Y232 CDYL1_HUMAN Chromo PF00385 61-112, ECH_1 PF00378 363-594 Cdyl 1339956 Q9WTK2 CDYL_MOUSE # # Histone modification write Histone acetylation 12072557 # histone H4 # 12072557 Human CDY and mouse CDYL proteins exhibit histone acetyltransferase activity in vitro, with a strong preference for histone H4. #
CDYL2
(details) 		23030 chromodomain protein, Y-like 2 124359 Q8N8U2 CDYL2_HUMAN Chromo PF00385 7-57, ECH_1 PF00378 271-500 Cdyl2 1923046 Q9D5D8 CDYL2_MOUSE # # Histone modification read # 23455924 # histone H3K9me3 # 21774827 Many mouse chromodomain proteins are reported to bind H3K9me3 in vitro, including CDYL, CDYL2, CBX2, CBX4, CBX7 and M-phase phosphoprotein 8 (MPP8). #
CELF1
(details) 		2549 CUGBP Elav-like family member 1 (CELF-1) (50 kDa nuclear polyadenylated RNA-binding protein) (Bruno-like protein 2) (CUG triplet repeat RNA-binding protein 1) (CUG-BP1) (CUG-BP- and ETR-3-like factor 1) (Deadenylation factor CUG-BP) (Embryo deadenylation element-binding protein homolog) (EDEN-BP homolog) (RNA-binding protein BRUNOL-2) 10658 Q92879 CELF1_HUMAN RRM_1 PF00076 19-85 110-174 403-473 Celf1 1342295 P28659 CELF1_MOUSE RBM RNA binding motif containing RNA modification Alternative splicing 11158314, 12649496 # RNA mRNA # 11158314, 12649496 Regulates MSE-dependent alternative splicing of cTNT during development in vertebrates. New
CELF2
(details) 		2550 CUGBP Elav-like family member 2 (CELF-2) (Bruno-like protein 3) (CUG triplet repeat RNA-binding protein 2) (CUG-BP2) (CUG-BP- and ETR-3-like factor 2) (ELAV-type RNA-binding protein 3) (ETR-3) (Neuroblastoma apoptosis-related RNA-binding protein) (hNAPOR) (RNA-binding protein BRUNOL-3) 10659 O95319 CELF2_HUMAN RRM_1 PF00076 43-110 134-198 425-495 Celf2 1338822 Q9Z0H4 CELF2_MOUSE RBM RNA binding motif containing RNA modification Alternative splicing 11158314, 12649496 # RNA mRNA # 11158314, 12649496 Regulates MSE-dependent alternative splicing of cTNT during development in vertebrates. New
CELF3
(details) 		11967 CUGBP Elav-like family member 3 (CELF-3) (Bruno-like protein 1) (CAG repeat protein 4) (CUG-BP- and ETR-3-like factor 3) (ELAV-type RNA-binding protein 1) (ETR-1) (Expanded repeat domain protein CAG/CTG 4) (RNA-binding protein BRUNOL-1) (Trinucleotide repeat-containing gene 4 protein) 11189 Q5SZQ8 CELF3_HUMAN RRM_1 PF00076 9-75 97-161 382-452 Celf3 1926034 Q8CIN6 CELF3_MOUSE RBM RNA binding motif containing RNA modification Alternative splicing 11158314, 12649496 # RNA mRNA # 11158314, 12649496 Regulates MSE-dependent alternative splicing of cTNT during development in vertebrates. New
CELF4
(details) 		14015 CUGBP Elav-like family member 4 (CELF-4) (Bruno-like protein 4) (CUG-BP- and ETR-3-like factor 4) (RNA-binding protein BRUNOL-4) 56853 Q9BZC1 CELF4_HUMAN RRM_1 PF00076 56-121 154-216 442-473 Celf4 1932407 Q7TSY6 CELF4_MOUSE RBM RNA binding motif containing RNA modification Alternative splicing 11158314, 12649496 # RNA mRNA # 11158314, 12649496 Regulates MSE-dependent alternative splicing of cTNT during development in vertebrates. New
CELF5
(details) 		14058 CUGBP Elav-like family member 5 (CELF-5) (Bruno-like protein 5) (CUG-BP- and ETR-3-like factor 5) (RNA-binding protein BRUNOL-5) 60680 Q8N6W0 CELF5_HUMAN RRM_1 PF00076 47-112 136-198 402-472 Celf5 2442333 D3Z4T1 D3Z4T1_MOUSE RBM RNA binding motif containing RNA modification Alternative splicing 11158314, 12649496 # RNA mRNA # 11158314, 12649496 Regulates MSE-dependent alternative splicing of cTNT during development in vertebrates. New
CELF6
(details) 		14059 CUGBP Elav-like family member 6 (CELF-6) (Bruno-like protein 6) (CUG-BP- and ETR-3-like factor 6) (RNA-binding protein BRUNOL-6) 60677 Q96J87 CELF6_HUMAN RRM_1 PF00076 48-113 136-199 398-468 Celf6 1923433 Q7TN33 CELF6_MOUSE RBM RNA binding motif containing RNA modification Alternative splicing 11158314, 12649496 # RNA mRNA # 11158314, 12649496 Regulates MSE-dependent alternative splicing of cTNT during development in vertebrates. New
CHD1
(details) 		1915 chromodomain helicase DNA binding protein 1 1105 O14646 CHD1_HUMAN Chromo PF00385 313-351 389-443, SNF2-rel_dom PF00176 482-764, Helicase_C PF00271 789-902, CDH1_2_SANT_HL1 PF18375 1124-1211, CHD1-like_C PF13907 1409-1500 Chd1 88393 P40201 CHD1_MOUSE # # Chromatin remodeling # 12592387 # DNA # # 12592387 These proteins have a DNA-binding domain as well as a chromodomain motif that can directly effect chromatin structure and gene transcription. There are currently four known members of this gene family in humans (CHD1–CHD4). #
CHD1L
(details) 		1916 chromodomain helicase DNA binding protein 1-like 9557 Q86WJ1 CHD1L_HUMAN SNF2-rel_dom PF00176 49-327, Helicase_C PF00271 348-459 Chd1l 1915308 Q9CXF7 CHD1L_MOUSE # # Chromatin remodeling # 19661379 # DNA # # 19661379 A chromatin-remodeling enzyme, ALC1 (Amplified in Liver Cancer 1, also known as CHD1L), that interacts with poly(ADP-ribose) and catalyzes PARP1-stimulated nucleosome sliding. #
CHD2
(details) 		1917 chromodomain helicase DNA binding protein 2 1106 O14647 CHD2_HUMAN Chromo PF00385 300-338 378-447, SNF2-rel_dom PF00176 487-767, Helicase_C PF00271 792-905, CDH1_2_SANT_HL1 PF18375 1129-1219, CHD1-like_C PF13907 1465-1553 Chd2 2448567 E9PZM4 CHD2_MOUSE # # Chromatin remodeling # 12592387 # DNA # # 12592387 These proteins have a DNA-binding domain as well as a chromodomain motif that can directly effect chromatin structure and gene transcription. There are currently four known members of this gene family in humans (CHD1–CHD4). #
CHD3
(details) 		1918 chromodomain helicase DNA binding protein 3 1107 Q12873 CHD3_HUMAN CHDNT PF08073 155-201, PHD PF00628 382-423 458-500, Chromo PF00385 630-682, SNF2-rel_dom PF00176 738-1034, Helicase_C PF00271 1061-1174, DUF1087 PF06465 1294-1350, CHDII_SANT-like PF06461 1376-1517, CHDCT2 PF08074 1737-1884 Chd3 1344395 # # PHF Zinc fingers, PHD-type Chromatin remodeling # 12592387 NuRD DNA # # 12592387 These proteins have a DNA-binding domain as well as a chromodomain motif that can directly effect chromatin structure and gene transcription. There are currently four known members of this gene family in humans (CHD1–CHD4). #
CHD4
(details) 		1919 chromodomain helicase DNA binding protein 4 1108 Q14839 CHD4_HUMAN CHDNT PF08073 165-217, PHD PF00628 373-414 452-493, Chromo PF00385 621-673, SNF2-rel_dom PF00176 728-1024, Helicase_C PF00271 1052-1164, DUF1087 PF06465 1291-1350, CHDII_SANT-like PF06461 1379-1520, CHDCT2 PF08074 1726-1872 Chd4 1344380 Q6PDQ2 CHD4_MOUSE PHF Zinc fingers, PHD-type Chromatin remodeling # 12592387 NuRD DNA # # 12592387 These proteins have a DNA-binding domain as well as a chromodomain motif that can directly effect chromatin structure and gene transcription. There are currently four known members of this gene family in humans (CHD1–CHD4). #
CHD5
(details) 		16816 chromodomain helicase DNA binding protein 5 26038 Q8TDI0 CHD5_HUMAN CHDNT PF08073 149-200, PHD PF00628 346-387 418-460, Chromo PF00385 590-643, SNF2-rel_dom PF00176 701-998, Helicase_C PF00271 1025-1138, DUF1087 PF06465 1299-1354, CHDII_SANT-like PF06461 1383-1527, CHDCT2 PF08074 1733-1879 Chd5 3036258 A2A8L1 CHD5_MOUSE PHF Zinc fingers, PHD-type Chromatin remodeling # 12592387 # histone H3K27me3, H3K4 # 12592387, 23948251 A novel gene encoding a protein with chromatin remodeling, helicase and DNA-binding motifs. This gene (CHD5) is the fifth member of the CHD gene family identified in humans. #
CHUK
(details) 		1974 conserved helix-loop-helix ubiquitous kinase 1147 O15111 IKKA_HUMAN Pkinase PF00069 16-290, IKBKB_SDD PF18397 387-658, IKKbetaNEMObind PF12179 708-744 Chuk 99484 Q60680 IKKA_MOUSE # # Histone modification write Histone phosphorylation 17434128 # histone H3 # 17434128 In the nucleus, IKKα=CHUK is recruited to the promoter region of the NF-κB-regulated genes by interacting with CBP, and contributes to NF-κB-mediated gene expressions through phosphorylation of histone H3. #
CTCFL
(details) 		16234 CCCTC-binding factor (zinc finger protein)-like 140690 Q8NI51 CTCFL_HUMAN zf-C2H2 PF00096 313-336 342-364 398-421 428-451 546-566 Ctcfl 3652571 A2APF3 CTCFL_MOUSE ZNF Zinc fingers, C2H2-type Chromatin remodeling # 18765639 # DNA # # 18765639 BORIS=CTCFL acts as a scaffold upon which BAT3 and SET1A assemble and through which BAT3 and SET1A exert their effects upon chromatin structure and gene expression. In contrast to CTCF, BORIS appears to be a methylation-independent DNA-binding protein (28b) that activates, rather than inhibits, gene expression. #
DDX21
(details) 		2744 DEAD (Asp-Glu-Ala-Asp) box helicase 21 9188 Q9NR30 DDX21_HUMAN DEAD PF00270 211-383, Helicase_C PF00271 434-532, GUCT PF08152 620-708 Ddx21 1860494 Q9JIK5 DDX21_MOUSE DDX DEAD-boxes RNA modification # 11237763 B-WICH RNA # # 11237763 Human RNA helicase II/Gu (hRH II/Gu) protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription. #
DMAP1
(details) 		18291 DNA methyltransferase 1 associated protein 1 55929 Q9NPF5 DMAP1_HUMAN SANT_DAMP1_like PF16282 124-202, DMAP1 PF05499 242-400 Dmap1 1913483 Q9JI44 DMAP1_MOUSE # # Chromatin remodeling # 14966270 NuA4, NuA4-related complex, SRCAP chromatin # # 14966270 SANT-domain protein DMAP1 links NuA4 to DNA replication and is also present in distinct proteins #
DNMT3L
(details) 		2980 DNA (cytosine-5-)-methyltransferase 3-like 29947 Q9UJW3 DNM3L_HUMAN ADD_DNMT3 PF17980 37-87, ADDz_Dnmt3b PF21255 96-146 Dnmt3l 1859287 Q9CWR8 DNM3L_MOUSE # # Histone modification read # 17687327 # histone H3K4 # 17687327 DNMT3L specifically interacts with the extreme amino terminus of histone H3, this interaction is strongly inhibited by methylation at lysine 4 of histone H3. #
DOT1L
(details) 		24948 DOT1-like histone H3K79 methyltransferase 84444 Q8TEK3 DOT1L_HUMAN DOT1 PF08123 117-317 Dot1l 2143886 - - KMT Chromatin-modifying enzymes / K-methyltransferases Histone modification write Histone methylation 12123582 # histone H3K79 # 12123582 Human DOT1-like (DOT1L) protein possesses intrinsic H3-K79-specific histone methyltransferase (HMTase) activity in vitro and in vivo. #
DPY30
(details) 		24590 dpy-30 homolog (C. elegans) 84661 Q9C005 DPY30_HUMAN Dpy-30 PF05186 52-92 Dpy30 1913560 Q99LT0 DPY30_MOUSE # # Histone modification write cofactor Histone methylation 19556245 COMPASS, Menin-associated_HMT, MLL-HCF, CHD8, MLL2/3, COMPASS-like MLL1,2, MLL4/WBP7, COMPASS-like MLL3,4 histone # # 19556245 The isolated MLL1 SET domain is an H3K4 monomethyltransferase. When the MLL1 SET domain fragment is assembled with a complex containing WDR5, RbBP5, Ash2L, and DPY-30, the rate of lysine methylation is dramatically increased, but only to the dimethyl form of H3K4, suggesting that the MLL1 core complex is predominantly a dimethyltransferase. #
DTX3L
(details) 		30323 deltex 3 like, E3 ubiquitin ligase 151636 Q8TDB6 DTX3L_HUMAN DTX3L_a-b PF21717 134-194, DTX3L_KH-like PF21718 235-357 373-508, zf-C3HC4_2 PF13923 561-599, DTC PF18102 608-739 Dtx3l 2656973 Q3UIR3 DTX3L_MOUSE RNF RING-type (C3HC4) zinc fingers Histone modification write Histone ubiquitination 19818714 # histone H4K91 # 19818714 BBAP=DTX3L selectively monoubiquitylates histone H4 lysine 91 and protects cells exposed to DNA-damaging agents. #
EEF1AKMT3
(details) 		24936 EEF1A lysine methyltransferase 3 25895 Q96AZ1 EFMT3_HUMAN Methyltransf_16 PF10294 38-195 Eef1akmt3 3645330 D3YWP0 EFMT3_MOUSE METTL Methyltransferase like Protein modification Protein methylation 28108655 # protein Lys165 of eEF1A K165m 28108655 Modulates mRNA translation New
EEF1AKNMT
(details) 		24248 eEF1A lysine and N-terminal methyltransferase 51603 Q8N6R0 EFNMT_HUMAN domain PF13649 53-157, Spermine_synth PF01564 493-616 Eef1aknmt 1918699 Q91YR5 EFNMT_MOUSE METTL Methyltransferase like Protein modification Protein methylation 30143613 # protein Lys55 of eEF1A K55m 30143613 Modulates mRNA translation New
EHMT1
(details) 		24650 euchromatic histone-lysine N-methyltransferase 1 79813 Q9H9B1 EHMT1_HUMAN EHMT1-2_CRR PF21533 539-633, Ank_4 PF13637 772-836, Ank_2 PF12796 838-904 907-990, Pre-SET PF05033 1015-1118, SET PF00856 1137-1243 Ehmt1 1924933 Q5DW34 EHMT1_MOUSE KMT, ANKRD Chromatin-modifying enzymes / K-methyltransferases, Ankyrin repeat domain containing Histone modification write Histone methylation 18264113 # histone H3K9 H3K9me1, H3K9me2 18264113 G9a and G9a-like protein (GLP)=EHMT1 are euchromatin-associated methyltransferases that repress transcription by mono- and dimethylating histone H3 at Lys9 (H3K9). #
EHMT2
(details) 		14129 euchromatic histone-lysine N-methyltransferase 2 10919 Q96KQ7 EHMT2_HUMAN EHMT1-2_CRR PF21533 447-540, Ank_2 PF12796 655-746 750-816, Ank PF00023 850-882, Pre-SET PF05033 927-1030, SET PF00856 1049-1155 Ehmt2 2148922 Q9Z148 EHMT2_MOUSE KMT, ANKRD Chromatin-modifying enzymes / K-methyltransferases, Ankyrin repeat domain containing Histone modification write Histone methylation 18264113 # histone H3K9 H3K9me1, H3K9me2 18264113 G9a=EHMT2 and G9a-like protein (GLP) are euchromatin-associated methyltransferases that repress transcription by mono- and dimethylating histone H3 at Lys9 (H3K9). #
EIF4A3
(details) 		18683 Eukaryotic initiation factor 4A-III (eIF-4A-III) (eIF4A-III) (EC 3.6.4.13) (ATP-dependent RNA helicase DDX48) (ATP-dependent RNA helicase eIF4A-3) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Eukaryotic translation initiation factor 4A isoform 3) (Nuclear matrix protein 265) (NMP 265) (hNMP 265) [Cleaved into: Eukaryotic initiation factor 4A-III, N-terminally processed] 9775 P38919 IF4A3_HUMAN DEAD PF00270 63-225, Helicase_C PF00271 264-372 EIf4A3 1923731 Q91VC3 IF4A3_MOUSE DDX DEAD-box helicases RNA modification Alternative splicing 22203037 # RNA mRNA # 22203037 Production of the proapoptotic Bcl-x(S) splice variant. New
ELP5
(details) 		30617 elongator acetyltransferase complex subunit 5 23587 Q8TE02 ELP5_HUMAN Elong_Iki1 PF10483 11-181 222-281 Elp5 1859017 Q99L85 ELP5_MOUSE ELP Elongator acetyltransferase complex subunits Histone modification write cofactor Histone acetylation 11904415 Pol2 elongator histone H3K14, H4K8 # 11904415 The elongating, hyperphosphorylated form of RNA polymerase II is associated with the Elongator complex, which has the histone acetyltransferase (HAT) Elp3 as a subunit. The three smallest Elongator subunits--Elp4, Elp5, and Elp6--are required for HAT activity, and Elongator binds to both naked and nucleosomal DNA. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. #
EPC1
(details) 		19876 enhancer of polycomb homolog 1 (Drosophila) 80314 Q9H2F5 EPC1_HUMAN EPL1 PF10513 6-148, E_Pc_C PF06752 581-836 Epc1 1278322 Q8C9X6 EPC1_MOUSE # # Polycomb group (PcG) protein # 14966270 NuA4, Piccolo_NuA4, NuA4-related complex histone # # 14966270 The Enhancer of Polycomb homology domain of human EPC1, like Epl1 in yeast (7), is a conserved functional key for histone acetylation since it bridges the MYST HAT with the ING protein to enable potent nucleosome histone acetyltransferase activity. #
ERBB4
(details) 		3432 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4 2066 Q15303 ERBB4_HUMAN Recep_L_domain PF01030 55-166 358-477, Furin-like PF00757 184-335, GF_recep_IV PF14843 502-633, TM_ErbB1 PF21314 653-687, PK_Tyr_Ser-Thr PF07714 718-974 Erbb4 104771 Q61527 ERBB4_MOUSE # # Histone modification cofactor # 23230144 # histone H3K9me3 # 23230144 ErbB4 intracellular domain (4ICD) that translocates into the nucleus to control gene expression through inhibiting an increase of H3K9me3. #
FAM175A
(details) 		25829 family with sequence similarity 175, member A 84142 Q6UWZ7 F175A_HUMAN MPN_2A_DUB_like PF21125 9-172 Fam175a 1917931 Q8BPZ8 F175A_MOUSE # # Scaffold protein # 19261749 BRCA1-A TF # # 19261749 Abra1=FAM175A protein, which appears to act as a scaffold for the A complex. Abra1 is known to mediate the interaction of Rap80 with BRCA1. #
FAM175B
(details) 		28975 family with sequence similarity 175, member B 23172 Q15018 F175B_HUMAN MPN_2A_DUB_like PF21125 3-167 Fam175b 1926116 Q3TCJ1 F175B_MOUSE # # Histone modification erase cofactor Histone ubiquitination 20656690 BRISC histone H2AK63 H2AK63ub 20656690 # #
FBRSL1
(details) 		29308 fibrosin-like 1 57666 Q9HCM7 FBSL_HUMAN Auts2 PF15336 587-788 Fbrsl1 1920907 # # # # Histone modification # 24217316, 22325352 RING2-FBRS histone # # 24217316, 22325352 Part of a RING2 complex. #
HCFC1
(details) 		4839 host cell factor C1 3054 P51610 HCFC1_HUMAN Kelch_1 PF01344 32-69, Kelch_5 PF13854 78-114 319-361, Kelch_3 PF13415 216-263 Hcfc1 105942 Q61191 HCFC1_MOUSE # # Chromatin remodeling # 12670868 NSL, COMPASS, MLL-HCF, CHD8, MLL2/3, COMPASS-like MLL1,2, MLL4/WBP7 chromatin # # 12670868 A series of molecular activities are associated with the N-terminal subunit of HCF-1 in HSV uninfected cells. Two of these activities are associated with opposing roles in the regulation of transcription through the modulation of chromatin structure: Sin3 HDAC and a novel human Set1/Ash2 HMT. #
HDAC1
(details) 		4852 histone deacetylase 1 3065 Q13547 HDAC1_HUMAN Hist_deacetyl PF00850 28-318 Hdac1 108086 O09106 HDAC1_MOUSE # # Histone modification erase Histone acetylation 10220385 SWI/SNF_Brm, NuRD, BHC, MeCP1, mSin3A, core HDAC, mSin3A-like complex, RING2-L3MBTL2, CREST-BRG1, LSD-CoREST histone H3, H4 # 10220385 HDAC1, HDAC4, HDAC5, and HDAC6 deacetylate all four core histones equally well, though deacetylation by HDAC4 and HDAC5 is incomplete. #
HDAC2
(details) 		4853 histone deacetylase 2 3066 Q92769 HDAC2_HUMAN Hist_deacetyl PF00850 29-319 Hdac2 1097691 P70288 HDAC2_MOUSE # # Histone modification erase Histone acetylation 9346952 SWI/SNF_Brg1(I), SWI/SNF_Brg1(II), SWI/SNF_Brm, NuRD, BHC, MeCP1, mSin3A, core HDAC, mSin3A-like complex, RING2-L3MBTL2, LSD-CoREST histone H2AKac, H2BKac, H3Kac, H4Kac H2AK, H2BK, H3K, H4K 9346952 HDAC1, HDAC2, and HDAC3 constitute a human HDAC family. All three proteins possess histone deacetylase activity, and repress transcription when bound to a promoter. #
HDGFL2
(details) 		14680 HDGF like 2 84717 Q7Z4V5 HDGR2_HUMAN PWWP PF00855 7-86, LEDGF PF11467 472-568 Hdgfrp2 1194492 Q3UMU9 HDGR2_MOUSE # # Histone modification read # 217205545 # histone H3K79me3, H4K20me3, H3K36me3 # 217205545 The crystal structures of the PWWP domains from seven different human proteins and three PWWP domain complex structures with histone peptides, i.e., BRPF1-H3K36me3, HDGF2-H3K79me3 and HDGF2-H4K20me3 shows that the PWWP domain can not only bind DNA but also histones. #
HLTF
(details) 		11099 helicase-like transcription factor 6596 Q14527 HLTF_HUMAN HIRAN PF08797 61-154, SNF2-rel_dom PF00176 242-720, zf-C3HC4_2 PF13923 760-800, Helicase_C PF00271 834-950 Hltf 1196437 Q6PCN7 HLTF_MOUSE RNF RING-type (C3HC4) zinc fingers Chromatin remodeling cofactor # 18719106 # chromatin # # 18719106 Acts as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA. #
IKBKAP
(details) 		5959 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein 8518 O95163 ELP1_HUMAN IKI3 PF04762 2-955 Ikbkap 1914544 Q7TT37 ELP1_MOUSE ELP Elongator acetyltransferase complex subunits Scaffold protein # 11818576, 11714725 Pol2 elongator # RNA # 11818576, 11714725 The human Elongator facilitates transcription by RNA polymerase II in a chromatin- and acetyl-CoA-dependent manner. Several human homologues of the yeast Elongator subunits have been identified as subunits of the human Elongator complex, including StIP1 (STAT-interacting protein 1) and IKAP (IKK complex-associated protein) =IKBKAP. #
IKZF1
(details) 		13176 IKAROS family zinc finger 1 (Ikaros) 10320 Q13422 IKZF1_HUMAN zf-C2H2 PF00096 145-167 173-195 201-224 Ikzf1 1342540 Q03267 IKZF1_MOUSE ZNF, IKZF Zinc fingers, C2H2-type, IKAROS zinc fingers Chromatin remodeling, TF # 19141594 # DNA DNA motif # 19141594 Ikaros=IKZF1 forms dimers and multimers efficiently, and it has been proposed that Ikaros induces heterochromatization or chromatin remodeling of mouse DNA, resulting in repression or activation of target genes. The results provide insight into possible structural and functional roles of pericentromeric regions in mouse and human chromosomes. #
IKZF3
(details) 		13178 IKAROS family zinc finger 3 (Aiolos) 22806 Q9UKT9 IKZF3_HUMAN zf-C2H2 PF00096 146-168 202-222 Ikzf3 1342542 O08900 IKZF3_MOUSE ZNF, IKZF Zinc fingers, C2H2-type, "IKAROS zinc fingers" TF # # # DNA DNA motif # # Associates with histone deacetylase complexes containing HDAC1, MTA2 and SIN3A. (UniProt) #
ING2
(details) 		6063 inhibitor of growth family, member 2 3622 Q9H160 ING2_HUMAN ING PF12998 27-122 Ing2 1916510 Q9ESK4 ING2_MOUSE PHF Zinc fingers, PHD-type Histone modification read # 16728974 mSin3A-like complex histone H3K4me3 # 16728974 ING2, a native subunit of a repressive mSin3a-HDAC1 histone deacetylase complex, binds with high affinity to the trimethylated species. In response to DNA damage, recognition of H3K4me3 by the ING2 PHD domain stabilizes the mSin3a-HDAC1 complex at the promoters of proliferation genes. #
JADE1
(details) 		30027 jade family PHD finger 1 79960 Q6IE81 JADE1_HUMAN EPL1 PF10513 17-181, PHD_2 PF13831 218-251, zf-HC5HC2H_2 PF13832 256-369 Jade1 1925835 Q6ZPI0 JADE1_MOUSE PHF Zinc fingers, PHD-type Histone modification write Histone acetylation 16387653 HBO1 histone H3, H4 H3ac, H4ac 16387653 HBO1-JADE(1,2,3=PHF15,PHF16,PHF17)-ING-hEAF6 tetramer complexes are likely responsible for the majority of histone H4 acetylation higher eukaryotes. #
JADE2
(details) 		22984 jade family PHD finger 2 23338 Q9NQC1 JADE2_HUMAN EPL1 PF10513 16-177, PHD_2 PF13831 214-247, zf-HC5HC2H_2 PF13832 253-364 Jade2 1924151 Q6ZQF7 JADE2_MOUSE PHF Zinc fingers, PHD-type Histone modification write Histone acetylation 16387653 HBO1 histone H3, H4 H3ac, H4ac 16387653 HBO1-JADE(1,2,3=PHF15,PHF16,PHF17)-ING-hEAF6 tetramer complexes are likely responsible for the majority of histone H4 acetylation higher eukaryotes. #
KAT8
(details) 		17933 K(lysine) acetyltransferase 8 84148 Q9H7Z6 KAT8_HUMAN Tudor-knot PF11717 54-110, zf-MYST PF17772 176-230, MOZ_SAS PF01853 235-412 Kat8 1915023 Q9D1P2 KAT8_MOUSE KAT, ZC2HC Chromatin-modifying enzymes / K-acetyltransferases, Zinc fingers, C2HC-type containing Histone modification write Histone acetylation 10786633 NSL, CHD8, MLL2/3, COMPASS-like MLL1,2, MLL4/WBP7 histone H2A, H3, H4 H2Aac, H3ac, H4ac 10786633 A recombinant C-terminal portion of hMOF=KAT8 has histone acetyltransferase activity directed toward histones H3, H2A and H4, a specificity characteristic of other MYST family histone acetyltransferases. #
KDM2A
(details) 		13606 lysine (K)-specific demethylase 2A 22992 Q9Y2K7 KDM2A_HUMAN JHD PF17811 304-343, zf-CXXC PF02008 565-609, PHD_4 PF16866 615-676, F-box-like PF12937 896-935 Kdm2a 1354736 P59997 KDM2A_MOUSE FBXL, KDM F-boxes / Leucine-rich repeats, Chromatin-modifying enzymes / K-demethylases Histone modification erase Histone methylation 20417597 # histone H3K36me2 H3K36 20417597 CpG islands directly recruit the H3K36-specific lysine demethylase enzyme KDM2A. Nucleation of KDM2A at these elements results in removal of H3K36 methylation, creating CpG island chromatin that is uniquely depleted of this modification. #
KDM2B
(details) 		13610 lysine (K)-specific demethylase 2B 84678 Q8NHM5 KDM2B_HUMAN Cupin_8 PF13621 150-331, JHD PF17811 334-375, zf-CXXC PF02008 607-651, PHD_4 PF16866 657-723, F-box-like PF12937 1068-1107 Kdm2b 1354737 Q6P1G2 KDM2B_MOUSE FBXL, KDM F-boxes / Leucine-rich repeats, Chromatin-modifying enzymes / K-demethylases Histone modification erase Histone methylation 17994099 BCOR histone H3K4me3, H3K36me2 H3K4, H3K36 17994099 JHDM1B =KDM2B is a histone demethylase that catalyses the demethylation of H3K4me3. #
KDM6A
(details) 		12637 lysine (K)-specific demethylase 6A 7403 O15550 KDM6A_HUMAN TPR_8 PF13181 205-237, JmjC PF02373 1133-1241, KDM6_C-hel PF21322 1248-1303, KDM6_GATAL PF21326 1320-1380 Kdm6a 1095419 O70546 KDM6A_MOUSE KDM, TTC Chromatin-modifying enzymes / K-demethylases, Tetratricopeptide (TTC) repeat domain containing Histone modification erase Histone methylation 17851529 CHD8, MLL2/3, MLL4/WBP7, COMPASS-like MLL3,4 histone H3K27me2. H3K27me3 H3K27 17851529 The JmjC-domain-containing proteins UTX=KDM6A and JMJD3 catalyse demethylation of H3K27me3/2. #
KEAP1
(details) 		23177 kelch-like ECH-associated protein 1 9817 Q14145 KEAP1_HUMAN BTB PF00651 67-178, BACK PF07707 184-285, Kelch_1 PF01344 327-359 361-410 412-457 459-504 507-551 553-598 Keap1 1858732 Q9Z2X8 KEAP1_MOUSE KLHL, BTBD Kelch-like, "BTB/POZ domain containing" Chromatin remodeling # 21920360 # chromatin # # # Interacts with the NURF Nucleosome Remodeling Factor complex. #
KLF18
(details) 		51793 Kruppel like factor 18 105378952 A0A0U1RQI7 KLF18_HUMAN zf-C2H2 PF00096 994-1018 1024-1046 Zfp352 2387418 A2AML7 A2AML7_MOUSE KLF Kruppel like factors TF # 24244731 # DNA DNA # 24244731 # New
KMT2A
(details) 		7132 lysine (K)-specific methyltransferase 2A 4297 Q03164 KMT2A_HUMAN zf-CXXC PF02008 1149-1194, PHD PF00628 1481-1530 1569-1624, zf-HC5HC2H PF13771 1897-1978, FYRN PF05964 2016-2077, FYRC PF05965 3666-3747, SET PF00856 3840-3945 Kmt2a 96995 P55200 KMT2A_MOUSE KMT, PHF Chromatin-modifying enzymes / K-methyltransferases, Zinc fingers, PHD-type Histone modification write Histone methylation 19187761 MLL-HCF, CHD8, COMPASS-like MLL1,2 histone H3K4 H3K4me 19187761 MLL1 SET domain can incorporate methyl groups into unmodified or H3K4me1 substrates, signifying both mono- and dimethylation activity. #
KMT2B
(details) 		15840 lysine (K)-specific methyltransferase 2B 9757 Q9UMN6 KMT2B_HUMAN zf-CXXC PF02008 959-1005, PHD PF00628 1203-1250 1251-1300 1337-1393, zf-HC5HC2H PF13771 1605-1685, FYRN PF05964 1731-1784, FYRC PF05965 2415-2494, SET PF00856 2580-2691 Kmt2b 109565 O08550 KMT2B_MOUSE KMT Chromatin-modifying enzymes / K-methyltransferases Histone modification write Histone methylation 17707229 Menin-associated_HMT, MLL2/3, COMPASS-like MLL3,4 histone H3K4 H3K4me3 17707229 MLL (=KMT2B)-containing complexes methylate histone H3 at lysine 4 (H3K4) and have been implicated in the regulation of transcription. #
KMT2C
(details) 		13726 lysine (K)-specific methyltransferase 2C 58508 Q8NEZ4 KMT2C_HUMAN zf-HC5HC2H PF13771 248-331, PHD PF00628 343-389 390-436 466-519 958-1008, zf-HC5HC2H_2 PF13832 4401-4506, FYRN PF05964 4546-4604, FYRC PF05965 4608-4692, SET PF00856 4781-4887 Kmt2c 2444959 Q8BRH4 KMT2C_MOUSE KMT, PHF Chromatin-modifying enzymes / K-methyltransferases, Zinc fingers, PHD-type Histone modification write Histone methylation 20937768 MLL2/3, COMPASS-like MLL3,4 histone H3K4 H3K4me 20937768 In humans, multiple Set1-like HMT complexes with H3K4 HMT activities have been identified. Each of these complexes contains the SET domain-containing homologs of yeast Set1, including human Set1 (hSet1), MLL1 (mixed lineage leukemia 1, also known as MLL, HRX, ALL1, or KMT2A), MLL2 (mixed-lineage leukemia 2, also known as HRX2 or KMT2B), MLL3 (mixed-lineage leukemia 3, also known as HALR or KMT2C), and MLL4 (mixed-lineage leukemia 4, also known as ALR or KMT2D), which carry the enzymatic activity for the associated complexes. #
KMT2D
(details) 		7133 lysine (K)-specific methyltransferase 2D 8085 O14686 KMT2D_HUMAN zf-HC5HC2H PF13771 139-218, PHD PF00628 228-274 276-321 1379-1428 1429-1474, zf-HC5HC2H_2 PF13832 5031-5136, FYRN PF05964 5176-5233, FYRC PF05965 5236-5322, SET PF00856 5408-5513 Kmt2d 2682319 Q6PDK2 KMT2D_MOUSE KMT, PHF Chromatin-modifying enzymes / K-methyltransferases, Zinc fingers, PHD-type Histone modification write Histone methylation 20937768 COMPASS-like MLL1,2, MLL4/WBP7, COMPASS-like MLL3,4 histone H3K4 H3K4me 20937768 In humans, multiple Set1-like HMT complexes with H3K4 HMT activities have been identified. Each of these complexes contains the SET domain-containing homologs of yeast Set1, including human Set1 (hSet1), MLL1 (mixed lineage leukemia 1, also known as MLL, HRX, ALL1, or KMT2A), MLL2 (mixed-lineage leukemia 2, also known as HRX2 or KMT2B), MLL3 (mixed-lineage leukemia 3, also known as HALR or KMT2C), and MLL4 (mixed-lineage leukemia 4, also known as ALR or KMT2D), which carry the enzymatic activity for the associated complexes. #
L3MBTL1
(details) 		15905 l(3)mbt-like 1 (Drosophila) 26013 Q9Y468 LMBL1_HUMAN MBT PF02820 310-377 417-484 521-586, zf-C2HC PF01530 622-650 L3mbtl1 2676663 A2A5N8 LMBL1_MOUSE ZC2HC, SAMD Zinc fingers, C2HC-type containing, Sterile alpha motif (SAM) domain containing Histone modification read # 18026117 L3MBTL1 histone H1BK26, H4K20 # 18026117 Crystal structures of the L3MBTL1 MBT repeats in complex with histone H4 peptides dimethylated on Lys20 (H4K20me2). Only the second of the three MBT repeats can bind mono- and dimethylated histone peptides. Its binding pocket has similarities to that of 53BP1 and is able to recognize the degree of histone lysine methylation. #
L3MBTL2
(details) 		18594 l(3)mbt-like 2 (Drosophila) 83746 Q969R5 LMBL2_HUMAN zf-FCS_1 PF21319 87-118, MBT PF02820 214-286 327-390 432-503 540-604 L3mbtl2 2443584 P59178 LMBL2_MOUSE # # Histone modification read # 19233876 RING2-L3MBTL2 histone H3K4, H3K9, H3K27, H4K20 # 19233876 Methylation-state-specific recognition of histones by the MBT repeat protein L3MBTL2. #
L3MBTL3
(details) 		23035 l(3)mbt-like 3 (Drosophila) 84456 Q96JM7 LMBL3_HUMAN MBT PF02820 268-335 375-441 479-544, SAM_1 PF00536 707-770 L3mbtl3 2143628 Q8BLB7 LMBL3_MOUSE SAMD Sterile alpha motif (SAM) domain containing Histone modification read # 23292653 # histone H4K20me # 23292653 Binds L3MBTL3 with a similar affinity to H4K20me histone #
L3MBTL4
(details) 		26677 l(3)mbt-like 4 (Drosophila) 91133 Q8NA19 LMBL4_HUMAN MBT PF02820 88-155 196-263 300-366, zf-C2HC PF01530 379-407, SAM_1 PF00536 543-605 L3mbtl4 2444889 B1B1A0 LMBL4_MOUSE SAMD Sterile alpha motif (SAM) domain containing Histone modification read # 20698951 # histone HKme # 20698951 The L3MBTL4 protein contains three "malignant brain tumor" (MBT) domains. The MBT domain binds methylated histone residues. #
LAS1L
(details) 		25726 LAS1-like (S. cerevisiae) 81887 Q9Y4W2 LAS1L_HUMAN Las1 PF04031 43-187 Las1l 1923380 A2BE28 LAS1L_MOUSE # # Histone modification write cofactor, Histone modification write cofactor Histone methylation, Histone acetylation 20442285 CHD8, MLL2/3, MLL4/WBP7 histone H3K4, H3,H4,H2A H3K4me, H3K4me2, H3Ac, H4Ac, H2AAc 15960975 Facultative member of the MLL1/MLL complex. #
MASTL
(details) 		19042 microtubule associated serine/threonine kinase-like 84930 Q96GX5 GWL_HUMAN Pkinase PF00069 36-188 736-835 Mastl 1914371 Q8C0P0 GWL_MOUSE # # Histone modification write Histone phosphorylation 20818157 # histone H1, H3 H1p, H3p 20818157 Phosphorylates histone protein in vitro; however such activity is unsure in vivo (UniProt). #
MBNL1
(details) 		6923 Muscleblind-like protein 1 (Triplet-expansion RNA-binding protein) 4154 Q9NR56 MBNL1_HUMAN zf-CCCH_2 PF14608 19-39, domain PF22628 48-86 216-253, zf-CCCH PF00642 183-205 Mbnl1 1928482 Q9JKP5 MBNL1_MOUSE ZC3H Zinc fingers CCCH-type RNA modification Alternative splicing 16946708, 19470458, 15257297 # RNA mRNA # 16946708, 19470458, 15257297 Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonistic regulator with CELF proteins. New
MBNL3
(details) 		20564 Muscleblind-like protein 3 (Cys3His CCG1-required protein) (Muscleblind-like X-linked protein) (Protein HCHCR) 55796 Q9NUK0 MBNL3_HUMAN zf-CCCH_2 PF14608 20-40, domain PF22628 49-87 211-248, zf-CCCH_4 PF18044 179-200 Mbnl3 2444912 Q8R003 MBNL3_MOUSE ZC3H Zinc fingers CCCH-type RNA modification Alternative splicing 15257297 # RNA mRNA # 15257297 Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonistic regulator with CELF proteins. New
MEN1
(details) 		7010 multiple endocrine neoplasia I # O00255 MEN1_HUMAN Menin PF05053 4-499 550-610 Men1 1316736 O88559 MEN1_MOUSE # # Histone modification write cofactor Histone methylation 14992727 Menin-associated_HMT, MLL-HCF, CHD8, MLL2/3, COMPASS-like MLL1,2, MLL4/WBP7 histone H3K4 H3K4me 14992727, 15199122 Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4) (UniProt). #
METTL11B
(details) 		31932 methyltransferase like 11B 149281 Q5VVY1 NTM1B_HUMAN Methyltransf_PK PF05891 65-278 Mettl11b 2685053 B2RXM4 NTM1B_MOUSE METTL Methyltransferase like Histone modification writer Histone methylation 26543159 # protein CENP-A K55m 26543159 Regulates centromere function and mitosis New
METTL14
(details) 		29330 methyltransferase like 14 57721 Q9HCE5 MET14_HUMAN MT-A70 PF05063 186-363 Mettl14 2442926 Q3UIK4 MET14_MOUSE METTL Methyltransferase like RNA modification RNA methylation 24316715 WMM RNA A of mRNA m(6)A 24316715 Regulates mRNA stability, processing miRNA, DNA-reparation New
METTL16
(details) 		28484 methyltransferase like 16 79066 Q86W50 MET16_HUMAN Methyltransf_10 PF05971 1-291 Mettl16 1914743 Q9CQG2 MET16_MOUSE METTL Methyltransferase like RNA modification RNA methylation 29051200 # RNA U6 snRNA (A43) m6A43 32266935 Tunes snRNA–pre‐mRNA interactions, controls alternative splicing New
METTL21A
(details) 		30476 methyltransferase like 21A 151194 Q8WXB1 MT21A_HUMAN Methyltransf_16 PF10294 26-189 Mettl21a 1914349 Q9CQL0 MT21A_MOUSE METTL Methyltransferase like Protein modification Protein methylation # # protein Hsp70 Km3 23921388 Modulates the affinity of Hsp70 for targets New
METTL3
(details) 		17563 methyltransferase like 3 56339 Q86U44 MTA70_HUMAN MT-A70 PF05063 389-550 Mettl3 1927165 Q8C3P7 MTA70_MOUSE METTL Methyltransferase like RNA modification RNA methylation 24316715 WMM RNA A of mRNA m(6)A 24316715 Regulates mRNA stability, processing miRNA, DNA-reparation New
METTL4
(details) 		24726 methyltransferase like 4 64863 Q8N3J2 METL4_HUMAN MT-A70 PF05063 281-454 Mettl4 1924031 Q3U034 METL4_MOUSE METTL Methyltransferase like RNA modification, DNA modification RNA methylation, DNA methylation 30982744 # DNA, RNA A of DNA, U2 snRNA m(6)A 31913360 Regulates transcriptional silencing, Polycomb silencing, splicing regulation New
MINA
(details) 		19441 MYC induced nuclear antigen 84864 Q8IUF8 MINA_HUMAN JmjC_2 PF08007 137-261, ROXA-like_wH PF20514 331-431 Mina 1914264 Q8CD15 MINA_MOUSE # # Histone modification erase Histone methylation 19502796 # histone H3K9me3 H3K9 19502796 mdig=MINA is involved in demethylation of tri-methyl lysine 9 on histone H3. #
MLLT1
(details) 		7134 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 4298 Q03111 ENL_HUMAN YEATS PF03366 27-107, AHD PF17793 496-555 Mllt1 1927238 # # # # Chromatin remodeling cofactor # 23623499 SWI/SNF-like_EPAFa, SWI/SNF-like EPAFB chromatin # # 23623499 MLL-ENL (=MLLT1) inhibits polycomb repressive complex 1. #
MORF4L1
(details) 		16989 mortality factor 4 like 1 10933 Q9UBU8 MO4L1_HUMAN Tudor-knot PF11717 11-52, MRG PF05712 175-351 Morf4l1 1096551 P60762 MO4L1_MOUSE # # Histone modification read # 21423274 NuA4 histone H4 # 21423274 Table 1 in reference (MRG15 =MORF4L1). #
MORF4L2
(details) 		16849 mortality factor 4 like 2 9643 Q15014 MO4L2_HUMAN MRG PF05712 101-280 Morf4l2 1927167 Q9R0Q4 MO4L2_MOUSE # # Histone modification erase cofactor Histone acetylation 12963728 NuA4 histone # # 12963728 The FLJ10914 protein is associated with components of the TRRAP/TIP60 histone acetyltransferase complex and binds directly to the MORF4-related MRG15 and MRGX proteins. #
MOV10
(details) 		7200 Mov10 RISC complex RNA helicase 4343 Q9HCE1 MOV10_HUMAN MOV-10_N PF21632 15-85, MOV-10_Ig-like PF21633 119-240, Mov-10_helical PF21635 291-358, MOV-10_beta-barrel PF21634 358-448, AAA_11 PF13086 499-572 610-690, AAA_12 PF13087 699-921 Mov10 97054 P23249 MOV10_MOUSE # # # # 20543829 # histone # # # MOV10 may be directly involved in transcriptional silencing by PcG complexes. #
MST1
(details) 		7380 macrophage stimulating 1 (hepatocyte growth factor-like) 4485 P26927 HGFL_HUMAN PAN_1 PF00024 26-104, Kringle PF00051 109-186 190-268 283-361 370-448, Trypsin PF00089 485-704 Mst1 96080 P26928 HGFL_MOUSE # # Histone modification # 17320507 # histone # # # Classified as histone-modifying enzymes in paper. #
MUM1
(details) 		29641 melanoma associated antigen (mutated) 1 84939 Q2TAK8 MUM1_HUMAN PWP3A-B_N PF20887 1-105, MUM1-like_PWWP PF20884 411-484, PWP3A-B_C PF20886 561-707 Mum1 1915364 Q6DID5 MUM1_MOUSE # # Histone modification read # 217205545 # histone H3K36me, K3K79me, H4K20me # 217205545 The PWWP domains in BRPF1, BRPF2, HDGF2, MUM1 and the N-terminal PWWP domains of WHSC1 and WHSC1L1 show weak binding affinity to histones with H3K36, K3K79 or H4K20 #
MYSM1
(details) 		29401 Myb-like, SWIRM and MPN domains 1 114803 Q5VVJ2 MYSM1_HUMAN Myb_DNA-binding PF00249 120-163, SWIRM PF04433 382-461, JAB PF01398 576-679 Mysm1 2444584 Q69Z66 MYSM1_MOUSE # # Histone modification erase Histone ubiquitination 17707232 # histone H2Aub H2A 17707232 JAMM/MPN(+) domain-containing histone H2A deubiquitinase (2A-DUB, or KIAA1915/MYSM1) is specific for monoubiquitinated H2A (uH2A) that has permitted delineation of a strategy for specific regulatory pathways of gene activation. #
NAP1L1
(details) 		7637 nucleosome assembly protein 1-like 1 4673 P55209 NP1L1_HUMAN NAP PF00956 77-344 Nap1l1 1855693 P28656 NP1L1_MOUSE # # Histone chaperone # 18226242 # histone # # 18226242 Human Nucleosome Assembly Protein-1 (hNAP-1) =NAP1L1 is known to act as a histone chaperone that shuttles histones H2A/H2B into the nucleus, assembles nucleosomes and promotes chromatin fluidity, thereby affecting transcription of several cellular genes. #
NAP1L2
(details) 		7638 nucleosome assembly protein 1-like 2 4674 Q9ULW6 NP1L2_HUMAN NAP PF00956 111-408 Nap1l2 106654 P51860 NP1L2_MOUSE # # Histone modification cofactor # 21333655, 17591696 # histone H3, H4 # # Interacts with H3 and H4 and may be involved in regulation of acetylation. #
NAP1L4
(details) 		7640 nucleosome assembly protein 1-like 4 4676 Q99733 NP1L4_HUMAN NAP PF00956 65-338 Nap1l4 1316687 Q78ZA7 NP1L4_MOUSE # # Histone modification cofactor # 21333655 # histone H3, H4 # # Interacts with H3 and H4 and may be involved in regulation of acetylation. #
NCOA6
(details) 		15936 nuclear receptor coactivator 6 23054 Q14686 NCOA6_HUMAN NCOA6_TRADD-N PF13820 47-182 Ncoa6 1929915 Q9JL19 NCOA6_MOUSE # # Histone modification write cofactor Histone methylation 17500065 CHD8, MLL2/3, COMPASS-like MLL3,4 histone # # 17500065 Ectopically expressed PTIP is capable of interacting with DNA damage response proteins including 53BP1, while endogenous PTIP, and a novel protein PA1 are both components of a Set1-like histone methyltransferase (HMT) complex that also contains ASH2L, RBBP5, WDR5, hDPY-30, NCOA6, SET domain-containing HMTs MLL3 and MLL4, and substoichiometric amount of JmjC domain-containing putative histone demethylase UTX. #
NFRKB
(details) 		7802 nuclear factor related to kappaB binding protein 4798 Q6P4R8 NFRKB_HUMAN NFRKB_winged PF14465 375-480 Nfrkb 2442410 Q6PIJ4 NFRKB_MOUSE INO80 INO80 complex subunits Chromatin remodeling cofactor, TF # 16230350 Ino80 DNA DNA motif # 16230350 Five proteins appear to be unique to the human INO80 complex. NFRKB is a large (more than 1300 amino acids) protein. The C-terminal half of NFRKB contains low complexity, mucin-like repeats. #
NFYB
(details) 		7805 nuclear transcription factor Y, beta 4801 P25208 NFYB_HUMAN CBFD_NFYB_HMF PF00808 58-122 Nfyb 97317 P63139 NFYB_MOUSE # # Chromatin remodeling, TF TF activator 15243141, 23332751 # DNA DNA motif # 23332751 NF-Y is a sequence-specific transcription factor with nucleosome-like properties of nonspecific DNA binding and helps establish permissive chromatin modifications at CCAAT promoters. #
NTMT1
(details) 		23373 N-terminal Xaa-Pro-Lys N-methyltransferase 1 28989 Q9BV86 NTM1A_HUMAN Methyltransf_PK PF05891 8-222 Ntmt1 1913867 Q8R2U4 NTM1A_MOUSE METTL Methyltransferase like Histone modification writer Histone methylation 26543159 # protein CENP-A, CENP-B, RCC1 Km1/m2/m3, Rm, Pm 26543159 Regulates centromere function and mitosis New
PAGR1
(details) 		28707 PAXIP1 associated glutamate-rich protein 1 79447 Q9BTK6 PAGR1_HUMAN PAXIP1_C PF15364 88-226 2900092E17Rik 1914528 Q99L02 PAGR1_MOUSE # # Histone modification write cofactor, Histone modification write cofactor Histone methylation, Histone acetylation 17500065 CHD8, MLL2/3, MLL4/WBP7, COMPASS-like MLL3,4 histone # # 17500065 Component of the MLL2/MLL3 complex (UniProt). #
PAXIP1
(details) 		8624 PAX interacting (with transcription-activation domain) protein 1 22976 Q6ZW49 PAXI1_HUMAN PTCB-BRCT PF12738 102-165 710-771, BRCT PF00533 604-684, RTT107_BRCT_5 PF16770 860-947, BRCT_2 PF16589 973-1062 Paxip1 1890430 Q6NZQ4 PAXI1_MOUSE # # Histone modification write cofactor Histone methylation 17178841 CHD8, MLL2/3, MLL4/WBP7, COMPASS-like MLL3,4 histone H3K4 H3K4me3 17178841 ALR (MLL2) is a member of the human MLL family, which belongs to a larger SET1 family of histone methyltransferases. ALR is present within a stable multiprotein complex containing a cohort of proteins shared with other SET1 family complexes and several unique components, such as PTIP and the jumonji family member UTX. #
PCGF2
(details) 		12929 polycomb group ring finger 2 7703 P35227 PCGF2_HUMAN zf-C3HC4_2 PF13923 18-56, RAWUL PF16207 164-228 Pcgf2 99161 P23798 PCGF2_MOUSE RNF, PCGF RING-type (C3HC4) zinc fingers, Polycomb group ring fingers Polycomb group (PcG) protein # 21282530 PRC1 # # # 21282530 CBX7 and CBX8, two Polycomb (Pc) homologs that repress INK4a, both participate in PRC1-like complexes with at least two Posterior sex combs (Psc) proteins, MEL18 =PCGF2 and BMI1. #
PHF19
(details) 		24566 PHD finger protein 19 26147 Q5T6S3 PHF19_HUMAN Tudor_2 PF18104 43-78, PHD PF00628 99-148, Mtf2_C PF14061 531-578 Phf19 1921266 Q9CXG9 PHF19_MOUSE TDRD, PHF Tudor domain containing, Zinc fingers, PHD-type Chromatin remodeling, Histone modification write cofactor Histone acetylation 15563832 PRC2 histone # # 15563832 Based on motifs identified within the hPCL3 =PHF19 open reading frames, hPCL3 proteins are likely to be nuclear proteins that regulate transcription and/or chromatin structure. #
PHF20L1
(details) 		24280 PHD finger protein 20-like 1 51105 A8MW92 P20L1_HUMAN Tudor_2 PF18104 90-124, PHD20L1_u1 PF16660 309-439, PHD_5 PF20826 675-729 Phf20l1 2444412 Q8CCJ9 P20L1_MOUSE TDRD, PHF Tudor domain containing, Zinc fingers, PHD-type Histone modification read # 21423274 # histone H3K4me # 21423274 Table 1 in the reference. Via its PWWP domain it specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair rea #
PIWIL4
(details) 		18444 piwi-like RNA-mediated gene silencing 4 143689 Q7Z3Z4 PIWL4_HUMAN PAZ PF02170 272-405, Piwi PF02171 546-837 Piwil4 3041167 Q8CGT6 PIWL4_MOUSE AGO Argonaute/PIWI family Chromatin remodeling, Histone modification erase cofactor Histone methylation 17544373 # histone H3K9 # 17544373 Induced histone H3 lysine 9 methylation at the p16(Ink4a) (CDKN2A) locus. Suggests that PIWIL4 plays important roles in the chromatin-modifying pathway in human somatic cells. #
PRMT2
(details) 		5186 protein arginine methyltransferase 2 3275 P55345 ANM2_HUMAN SH3_1 PF00018 36-82, MTS PF05175 131-210, domain PF22528 244-415 Prmt2 1316652 Q9R144 ANM2_MOUSE PRMT Protein arginine methyltransferases Histone modification write Histone methylation 19405910 # histone H4 H4me 19405910 PRMT2 activity is substantially lower than PRMT1 in vitro, but both enzymes selectively methylate histone H4 and PRMT2, like PRMT1, may act as a transcription co-activator through this modification. #
PRMT8
(details) 		5188 protein arginine methyltransferase 8 56341 Q9NR22 ANM8_HUMAN PrmA PF06325 111-184, domain PF22528 217-380 Prmt8 3043083 Q6PAK3 ANM8_MOUSE PRMT Protein arginine methyltransferases Histone modification write Histone methylation 16051612 # histone H4R H4Rme 16051612 PRMT8 preferentially methylates histone H4 and the recombinant forms of GAR and Npl3, thus displaying PRMT1-like substrate specificity. #
RAD54L
(details) 		9826 RAD54-like (S. cerevisiae) 8438 Q92698 RAD54_HUMAN SNF2-rel_dom PF00176 156-462, Helicase_C PF00271 499-611 Rad54l 894697 P70270 RAD54_MOUSE # # Chromatin remodeling # 8805304 # chromatin # # 8805304 V(D)J recombination does not involve homologous recombination, but mHR54 =RAD54L could mediate a substrate preparation step that V(D)J and meiotic recombination have in common, such as changing the chromatin structure of the loci that will be rearranged. #
RAD54L2
(details) 		29123 RAD54-like 2 (S. cerevisiae) 23132 Q9Y4B4 ARIP4_HUMAN SNF2-rel_dom PF00176 274-598, Helicase_C PF00271 725-854 Rad54l2 1933196 Q99NG0 ARIP4_MOUSE # # Chromatin remodeling # 19692572 # chromatin # # 19692572 ARIP4 =RAD54L2 contains SNF2 domain that functions as a motor protein in chromatin remodeling complexes. #
RAG1
(details) 		9831 recombination activating gene 1 5896 P15918 RAG1_HUMAN RAG1_imp_bd PF12560 1-291, zf-C3HC4 PF00097 293-331, zf-RAG1 PF10426 354-383, RAG1 PF12940 387-1022 Rag1 97848 P15919 RAG1_MOUSE RNF RING-type (C3HC4) zinc fingers Histone modification write Histone ubiquitination 21256161 # histone, DNA H3.3K, DNA motif H3.3Kub 21256161 It has been suggested that RAG1 targets H3.3, the H3 variant known to be associated with recombining loci, and thus most likely to be encountered by RAG1 during V(D)J recombination. This reaction is absolutely dependent on an intact RAG1 RING domain, and requires regions of the far N-terminus of RAG1 where the H3.3 binding sight is likely to reside and regions within the H3 amino-terminal tail. Several H3.3 lysines are subject to ubiquitylation. #
RBBP4
(details) 		9887 retinoblastoma binding protein 4 5928 Q09028 RBBP4_HUMAN CAF1C_H4-bd PF12265 19-88, WD40 PF00400 173-206 221-256 265-302 309-346 367-402 Rbbp4 1194912 Q60972 RBBP4_MOUSE WDR WD repeat domain containing Histone chaperone # 8858152 NuRF, SWI/SNF_Brg1(I), SWI/SNF_Brg1(II), SWI/SNF_Brm, NuRD, mSin3A, core HDAC, mSin3A-like complex, PRC2, CAF-1 histone H4 # 8858152 RbAp46 and RbAp48 (pRB-associated proteins p46 and p48, also known as RBBP7 and RBBP4, respectively) are highly homologous histone chaperones that play key roles in establishing and maintaining chromatin structure. Human p48 =RBBP4 can bind to histone H4 in the absence of CAF-1 p150 and p60. p48, also a known subunit of a histone deacetylase, copurifies with a chromatin assembly complex (CAC), which contains the three subunits of CAF-1 (p150, p60, p48) and H3 and H4, and promotes DNA replication-dependent chromatin assembly. #
RBBP5
(details) 		9888 retinoblastoma binding protein 5 5929 Q15291 RBBP5_HUMAN WD40 PF00400 29-52 62-94 Rbbp5 1918367 Q8BX09 RBBP5_MOUSE WDR WD repeat domain containing Histone modification write cofactor Histone methylation 19556245 COMPASS, Menin-associated_HMT, MLL-HCF, CHD8, MLL2/3, COMPASS-like MLL1,2, MLL4/WBP7, COMPASS-like MLL3,4 histone H3K4 H3K4me1, H3K4me2, H3K4me3 19556245 A five-component 200-kDa MLL1 core complex containing human MLL1, WDR5, RbBP5, Ash2L, and DPY-30. #
RBBP7
(details) 		9890 retinoblastoma binding protein 7 5931 Q16576 RBBP7_HUMAN CAF1C_H4-bd PF12265 18-87, WD40 PF00400 172-205 220-255 264-301 308-345 366-402 Rbbp7 1194910 Q60973 RBBP7_MOUSE WDR WD repeat domain containing Histone chaperone # 18571423 NuRF, NuRD, mSin3A, core HDAC, mSin3A-like complex, PRC2 histone H4 # 18571423 RbAp46 and RbAp48 (pRB-associated proteins p46 and p48, also known as RBBP7 and RBBP4, respectively) are highly homologous histone chaperones that play key roles in establishing and maintaining chromatin structure. When a histone H3/H4 dimer (or tetramer) binds to RbAp46 or RbAp48, helix 1 of histone H4 unfolds to interact with the histone chaperone. #
RING1
(details) 		10018 ring finger protein 1 6015 Q06587 RING1_HUMAN zf-C3HC4_2 PF13923 47-87, RAWUL PF16207 282-400 Ring1 1101770 O35730 RING1_MOUSE RNF RING-type (C3HC4) zinc fingers Histone modification write, Polycomb group (PcG) protein Histone ubiquitination 15386022 PRC1, BCOR, RING2-L3MBTL2, RING2-FBRS histone H2AK119 H2AK119ub 15386022 The complex hPRC1L (human Polycomb repressive complex 1-like) is composed of several Polycomb-group proteins including Ring1, Ring2, Bmi1 and HPH2. hPRC1L monoubiquitinates nucleosomal histone H2A at lysine 119. #
RUVBL1
(details) 		10474 RuvB-like AAA ATPase 1 8607 Q9Y265 RUVB1_HUMAN TIP49 PF06068 14-368, TIP49_C PF17856 374-439 Ruvbl1 1928760 P60122 RUVB1_MOUSE INO80, AATP INO80 complex subunits, ATPases / AAA-type Chromatin remodeling, Histone modification write Histone phosphorylation 14695187 Ino80, SWR, NuA4, NuA4-related complex, CHD8, MLL2/3, MLL4/WBP7, SRCAP chromatin # # 14695187 The ability of TIP49=RUVBL1 to inhibit ITF-2 gene expression has been linked to decreased acetylation of histones in the vicinity of the TCF-binding sites in the ITF-2 promoter region. It has been suggested that TIP49 is an important cofactor in beta-catenin/TCF gene regulation in normal and neoplastic cells, likely functioning in chromatin remodeling. #
RUVBL2
(details) 		10475 RuvB-like AAA ATPase 2 10856 Q9Y230 RUVB2_HUMAN TIP49 PF06068 21-364, TIP49_C PF17856 370-435 Ruvbl2 1342299 Q9WTM5 RUVB2_MOUSE INO80, AATP INO80 complex subunits, ATPases / AAA-type Chromatin remodeling cofactor # 18026119 Ino80, SWR, NuA4, NuA4-related complex, CHD8, MLL2/3, MLL4/WBP7, SRCAP chromatin # # 18026119 The seven human INO80 complex components include TIP49A and TIP49B (previously identified as ‘RuvB-like’ proteins, and labeled RUVBL1 and RUVBL2). #
SAP30
(details) 		10532 Sin3A-associated protein, 30kDa 8819 O75446 SAP30_HUMAN zf-SAP30 PF13866 64-134, SAP30_Sin3_bdg PF13867 153-205 Sap30 1929129 O88574 SAP30_MOUSE # # Histone modification erase cofactor Histone acetylation 9651585 mSin3A, mSin3A-like complex histone # # 9651585 The human SAP30 complex is active in deacetylating core histone octamers. #
SAP30L
(details) 		25663 SAP30-like 79685 Q9HAJ7 SP30L_HUMAN zf-SAP30 PF13866 26-95, SAP30_Sin3_bdg PF13867 114-166 Sap30l 1354709 Q5SQF8 SP30L_MOUSE # # Histone modification erase cofactor Histone acetylation 16820529 # histone # # 16820529 SAP30L induces transcriptional repression, possibly via recruitment of Sin3A and histone deacetylases. A functional nucleolar localization signal in SAP30L means that SAP30L and SAP30 are able to target Sin3A to the nucleolus. #
SCML2
(details) 		10581 sex comb on midleg-like 2 (Drosophila) 10389 Q9UQR0 SCML2_HUMAN MBT PF02820 67-134 176-241, RBR PF17208 281-321, SLED PF12140 355-464, SAM_1 PF00536 628-695 # # # # SAMD Sterile alpha motif (SAM) domain containing Polycomb group (PcG) protein # 24727478 PRC1 # # # 24727478 Scml2 is a member of the Polycomb group of proteins involved in epigenetic gene silencing. Human Scml2 is a part of a multisubunit protein complex, PRC1 (Polycomb repressive complex 1), which is responsible for maintenance of gene repression, prevention of chromatin remodeling, preservation of the "stemness" of the cell, and cell differentiation. #
SCML4
(details) 		21397 sex comb on midleg-like 4 (Drosophila) 256380 Q8N228 SCML4_HUMAN RBR PF17208 1-61, SLED PF12140 96-207, SAM_1 PF00536 343-410 Scml4 2446140 Q80VG1 SCML4_MOUSE SAMD Sterile alpha motif (SAM) domain containing Polycomb group (PcG) protein # # # # # # # Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. (Annotated by similarity.) #
SFMBT1
(details) 		20255 Scm-like with four mbt domains 1 51460 Q9UHJ3 SMBT1_HUMAN MBT PF02820 54-121 166-234 279-351 388-454, SLED PF12140 501-616, SAM_1 PF00536 793-857 Sfmbt1 1859609 Q9JMD1 SMBT1_MOUSE # # Polycomb group (PcG) protein # 21423274 SCL histone H4K20 # 21423274 Table 1 in the reference. #
SFMBT2
(details) 		20256 Scm-like with four mbt domains 2 57713 Q5VUG0 SMBT2_HUMAN MBT PF02820 78-146 191-258 301-375 411-478, SLED PF12140 529-642, SAM_1 PF00536 823-885 Sfmbt2 2447794 Q5DTW2 SMBT2_MOUSE SAMD Sterile alpha motif (SAM) domain containing Histone modification read, Polycomb group (PcG) protein, TF TF repressor 23385818 # histone, DNA H3K9me2, H3K9me3, H3K27me3, H4K20me2, H4K20me3 H3, H4 23385818 SFMBT2 binds preferentially to methylated histone H3 and H4 that are associated with transcriptional repression. Occupancy of SFMBT2 coincide with enrichment of diand tri-methylated H3K9 and H4K20 as well as tri-methylated H3K27 at the HOXB13 gene promoter. #
SIN3A
(details) 		19353 SIN3 transcription regulator family member A 25942 Q96ST3 SIN3A_HUMAN PAH PF02671 142-186 323-380 478-522, Sin3_corepress PF08295 551-647, Sin3a_C PF16879 885-1192 Sin3a 107157 Q60520 SIN3A_MOUSE # # Histone modification erase cofactor, TF Histone acetylation, TF activator, TF repressor 12670868 SWI/SNF_Brg1(I), SWI/SNF_Brm, mSin3A, mSin3A-like complex histone, DNA DNA motif # 12670868 Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1. #
SMARCA4
(details) 		11100 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 6597 P51532 SMCA4_HUMAN QLQ PF08880 172-205, HSA PF07529 461-532, BRK PF07533 612-653, SNF2-rel_dom PF00176 754-1051, Helicase_C PF00271 1081-1194, SnAC PF14619 1321-1388, Bromodomain PF00439 1477-1547 Smarca4 88192 Q3TKT4 SMCA4_MOUSE # # Histone modification read, TF TF activator 17582821 BAF, nBAF, npBAF, PBAF, SWI/SNF_Brg1(I), SWI/SNF_Brg1(II), SWI/SNF_Brm, SWI/SNF-like_EPAFa, WINAC, SWI/SNF-like EPAFB, bBAF, SWI/SNF BRM-BRG1, CREST-BRG1 histone H3, H4 # 17582821 The BRG1 =SMARCA4 bromodomain exhibits binding, albeit weak, to acetylated peptides that are derived from histones H3 and H4. #
SMARCAL1
(details) 		11102 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 50485 Q9NZC9 SMAL1_HUMAN HARP PF07443 245-304 344-397, SNF2-rel_dom PF00176 439-688, Helicase_C PF00271 714-822 Smarcal1 1859183 Q8BJL0 SMAL1_MOUSE # # Chromatin remodeling # 11799392 # chromatin # # 11799392 The unique constellation of findings constituting SIOD indicates that SMARCAL1 regulates the transcriptional activity of a particular subset of genes through chromatin remodeling during both development and later life. #
SMARCB1
(details) 		11103 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 6598 Q12824 SNF5_HUMAN INI1_DNA-bd PF21459 12-104, SNF5 PF04855 180-373 Smarcb1 1328366 Q9Z0H3 SNF5_MOUSE # # Histone modification read # 21423274 BAF, nBAF, npBAF, PBAF, SWI/SNF_Brg1(I), SWI/SNF_Brg1(II), SWI/SNF_Brm, SWI/SNF-like_EPAFa, WINAC, SWI/SNF-like EPAFB, bBAF, SWI/SNF BRM-BRG1 histone H3K56 # 21423274 Table 1 in the reference (SMARCB1 =Snf5) #
SMARCC1
(details) 		11104 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 6599 Q92922 SMRC1_HUMAN SWIRM-assoc_2 PF16496 31-165, SWIRM PF04433 459-537, Myb_DNA-binding PF00249 622-664, SWIRM-assoc_3 PF16498 705-772, SWIRM-assoc_1 PF16495 872-952 Smarcc1 1203524 P97496 SMRC1_MOUSE # # Chromatin remodeling cofactor # 10078207 BAF, nBAF, npBAF, PBAF, SWI/SNF_Brg1(I), SWI/SNF_Brg1(II), SWI/SNF_Brm, SWI/SNF-like_EPAFa, WINAC, SWI/SNF-like EPAFB, bBAF, SWI/SNF BRM-BRG1 chromatin # # 10078207 The addition of INI1, BAF155 =SMARCC1, and BAF170 to BRG1 increases remodeling activity to a level comparable to that of the whole hSWI/SNF complex. #
SMARCC2
(details) 		11105 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 6601 Q8TAQ2 SMRC2_HUMAN SWIRM-assoc_2 PF16496 5-137, SWIRM PF04433 434-512, Myb_DNA-binding PF00249 600-642, SWIRM-assoc_3 PF16498 683-748, SWIRM-assoc_1 PF16495 864-945 Smarcc2 1915344 Q6PDG5 SMRC2_MOUSE # # Chromatin remodeling cofactor # 10078207 BAF, nBAF, npBAF, PBAF, SWI/SNF_Brg1(I), SWI/SNF_Brg1(II), SWI/SNF_Brm, SWI/SNF-like_EPAFa, WINAC, SWI/SNF-like EPAFB, bBAF, SWI/SNF BRM-BRG1 chromatin # # 10078207 The addition of INI1, BAF155, and BAF170 =SMARCC2 to BRG1 increases remodeling activity to a level comparable to that of the whole hSWI/SNF complex. #
SMARCD1
(details) 		11106 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 6602 Q96GM5 SMRD1_HUMAN SWIB PF02201 294-364 Smarcd1 1933623 Q61466 SMRD1_MOUSE # # Chromatin remodeling # 12917342 BAF, nBAF, npBAF, PBAF, SWI/SNF_Brg1(I), SWI/SNF_Brm, SWI/SNF-like_EPAFa, WINAC, SWI/SNF-like EPAFB, SWI/SNF BRM-BRG1 chromatin # # 12917342 BAF60a =SMARCD1 possesses at least two interaction surfaces, one for GR and BRG1 and a second for BAF155 and BAF170. A GR mutant, GR(R488Q), that fails to interact with BAF60a=SMARCD1 in vitro has reduced chromatin-remodeling activity and reduced transcriptional activity from the promoter assembled as chromatin in vivo. #
SMARCD2
(details) 		11107 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 6603 Q92925 SMRD2_HUMAN SWIB PF02201 310-379 Smarcd2 1933621 Q99JR8 SMRD2_MOUSE # # Chromatin remodeling cofactor # 20148946 BAF, PBAF, SWI/SNF_Brg1(I), SWI/SNF_Brm, SWI/SNF-like EPAFB, bBAF, SWI/SNF BRM-BRG1 chromatin # # 20148946 The SWI/SNF chromatin remodeling complexes are important regulators of transcription; they consist of large multisubunit assemblies containing either Brm or Brg1 as the catalytic ATPase subunit and a variable subset of approximately 10 Brg/Brm-associated factors (BAF). Among these factors, BAF60 proteins (BAF60a, BAF60b=SMARCD2 or BAF60c), which are found in most complexes, are thought to bridge interactions between transcription factors and SWI/SNF complexes. #
SMARCE1
(details) 		11109 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 6605 Q969G3 SMCE1_HUMAN HMG_box PF00505 66-134 Smarce1 1927347 O54941 SMCE1_MOUSE # # Chromatin remodeling cofactor # 12672490 BAF, nBAF, npBAF, PBAF, SWI/SNF_Brg1(I), SWI/SNF_Brg1(II), SWI/SNF_Brm, SWI/SNF-like_EPAFa, WINAC, SWI/SNF-like EPAFB, bBAF chromatin # # 12672490 In addition to Swi2/Snf2 proteins, there is evidence that other core components are required for chromatin-remodeling activity. More recently, two additional human Swi/Snf members, BAF57 =SMARCE1 and BAF60a, have been shown to interact directly with regulatory proteins. #
SS18L1
(details) 		15592 synovial sarcoma translocation gene on chromosome 18-like 1 26039 O75177 CREST_HUMAN SSXT PF05030 12-73 Ss18l1 2444061 Q8BW22 CREST_MOUSE # # Chromatin remodeling # 23799466 CREST-BRG1 chromatin # # 23799466 - #
SS18L2
(details) 		15593 synovial sarcoma translocation gene on chromosome 18-like 2 51188 Q9UHA2 S18L2_HUMAN SSXT PF05030 12-73 Deb1 1349474 Q9D174 S18L2_MOUSE # # Chromatin remodeling # 19163965, 8666667 # chromatin # # 15986999 # #
SSRP1
(details) 		11327 structure specific recognition protein 1 6749 Q08945 SSRP1_HUMAN POB3_N PF17292 3-96, SSrecog PF03531 105-170, PH1_SSRP1-like PF21103 197-327, Rttp106-like_middle PF08512 340-427, HMG_box PF00505 547-615, SSRP1_C PF21092 663-709 Ssrp1 107912 Q08943 SSRP1_MOUSE # # Chromatin remodeling # 12934006 FACT histone H3, H4 # 12934006 Both FACT and Spt16 can bind to nucleosomes and H2A-H2B dimers, whereas SSRP1 can only bind to H3-H4 tetramers but not to intact nucleosomes. Possibly, upon FACT binding to the nucleosome in the transcribed region, Spt16 facilitates the H2A-H2B displacement, which promotes the interaction between SSRP1 and the “altered” nucleosome. #
SUPT16H
(details) 		11465 suppressor of Ty 16 homolog (S. cerevisiae) 11198 Q9Y5B9 SP16H_HUMAN FACT-Spt16_Nlob PF14826 5-167, Peptidase_M24 PF00557 182-411, SPT16 PF08644 529-689, Rttp106-like_middle PF08512 809-895, SPT16_C PF21091 929-1031 Supt16 1890948 Q920B9 SP16H_MOUSE # # Histone modification read # 12934006 WINAC, FACT histone H2A, H2B # 12934006 Both FACT and Spt16=SUPT16H can bind to nucleosomes and H2A-H2B dimers, whereas SSRP1 can only bind to H3-H4 tetramers but not to intact nucleosomes. Possibly, upon FACT binding to the nucleosome in the transcribed region, Spt16 facilitates the H2A-H2B displacement, which promotes the interaction between SSRP1 and the “altered” nucleosome. #
SUPT3H
(details) 		11466 suppressor of Ty 3 homolog (S. cerevisiae) 8464 O75486 SUPT3_HUMAN TFIID-18kDa PF02269 26-115 # # # # # # Histone modification write cofactor Histone acetylation 11564863 PCAF, SAGA, STAGA histone # # 11564863 GCN5 is a histone acetyltransferase (HAT) originally identified in Saccharomyces cerevisiae and required for transcription of specific genes within chromatin as part of the SAGA (SPT-ADA-GCN5 acetylase) coactivator complex. Mammalian cells have two distinct GCN5 homologs (PCAF and GCN5L) that have been found in three different SAGA-like complexes (PCAF complex, TFTC [TATA-binding-protein-free TAFII-containing complex], and STAGA [SPT3-TAFII31-GCN5L acetylase]). #
SUPT7L
(details) 		30632 suppressor of Ty 7 (S. cerevisiae)-like 9913 O94864 ST65G_HUMAN Bromo_TP PF07524 151-228 Supt7l 1919445 Q9CZV5 ST65G_MOUSE # # Histone chaperone # 11564863 TFTC-HAT, STAGA histone # # 11564863 STAGA contains homologs of most yeast SAGA components, including two novel human proteins with histone-like folds and sequence relationships to yeast SPT7 and ADA1. STAGA preferentially acetylates histone H3 within nucleosomes. #
TADA1
(details) 		30631 transcriptional adaptor 1 117143 Q96BN2 TADA1_HUMAN SAGA-Tad1 PF12767 7-107 136-193 Tada1 1196415 Q99LM9 TADA1_MOUSE # # Histone chaperone # 11564863 STAGA histone H2A # 11564863 Within STAGA are two novel histone fold-containing protein subunits: STAF65γ, which is encoded by the KIAA0764 gene of previously unknown function, and STAF42=TADA1, a novel histone H2A-like protein. #
TAF1L
(details) 		18056 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like 138474 Q8IZX4 TAF1L_HUMAN TBP-binding PF09247 26-86, DUF3591 PF12157 583-1047, zf-CCHC_6 PF15288 1278-1322, Bromodomain PF00439 1409-1488 1536-1612 # # # # # # Histone modification read # 22464331 # histone H1.4ac, H2Aac, H2Bac, H3ac, H4ac # 22464331 Interacts (via bromo domains) with acetylated lysine residues on the N-terminus of histone H1.4, H2A, H2B, H3 and H4 (in vitro). #
TAF5L
(details) 		17304 TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa 27097 O75529 TAF5L_HUMAN TFIID_NTD2 PF04494 66-196, WD40 PF00400 269-296 334-370 379-412 418-454 459-496 501-538 Taf5l 1919039 Q91WQ5 TAF5L_MOUSE WDR WD repeat domain containing Histone modification write cofactor Histone acetylation 10373431 PCAF, TFTC-HAT, STAGA histone # # 10373431 The PCAF complex contains hPAF65β=TAF5L, a WD40 repeat-containing factor having similarity to Htafii100(row=423) (5). Antibodies raised against hPAF65β revealed a band around 65 kDa in both the PCAF and the TFTC complexes. #
TAF6L
(details) 		17305 TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa 10629 Q9Y6J9 TAF6L_HUMAN TAF PF02969 10-73, TAF6_C PF07571 155-327 Taf6l 2444957 Q8R2K4 TAF6L_MOUSE # # Histone chaperone # 12601814 PCAF, TFTC-HAT, STAGA histone # # 12601814 Human PAF65-alpha shows a strong sequence homology to TAFII80 and also contains a putative HFD. Thus, PAF65-alpha may also interact with TAFII32 in the TFTC complex. #
TAF9
(details) 		11542 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa 6880 Q16594 TAF9_HUMAN TFIID-31kDa PF02291 10-130 Taf9 1888697 Q8VI33 TAF9_MOUSE # # Histone chaperone # 9674425 PCAF, STAGA, CHD8, MLL2/3, MLL4/WBP7 DNA # # 9674425 Histone-like TAFs, including TAFII31 =TAF9, are found within the PCAF histone acetylase complex. #
TBL1XR1
(details) 		29529 transducin (beta)-like 1 X-linked receptor 1 79718 Q9BZK7 TBL1R_HUMAN LisH PF08513 6-32, WD40 PF00400 164-197 226-252 258-294 340-377 382-428 432-470 Tbl1xr1 2441730 Q8BHJ5 TBL1R_MOUSE WDR WD repeat domain containing # # 15601853 # histone # # # Targets Ncor repressive complex to deacethylated histones. #
TLE1
(details) 		11837 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) 7088 Q04724 TLE1_HUMAN TLE_N PF03920 18-132, WD40 PF00400 477-511 531-558 577-602 607-644 692-725 739-766 Tle1 104636 Q62440 TLE1_MOUSE WDR WD repeat domain containing Chromatin remodeling, Histone modification cofactor # 9334241, 17041588 # histone H3 # 9334241, 17041588 Native Groucho/TLE proteins interact specifically with histone H3 and not with other core histones. #
TLE2
(details) 		11838 transducin-like enhancer of split 2 7089 Q04725 TLE2_HUMAN TLE_N PF03920 18-130, WD40 PF00400 450-484 504-531 550-575 580-617 665-698 712-739 Tle2 104635 Q9WVB2 TLE2_MOUSE WDR WD repeat domain containing Histone modification cofactor # 17041588 # histone H3 H3K4, H3K9, H3K27me 17041588 CUL4-DDB1 complexes interact with multiple WD40-repeat proteins (WDRs) including TLE1-3, WDR5, L2DTL (also known as CDT2) and the Polycomb-group protein EED (also known as ESC). WDR5 and EED are core components of histone methylation complexes that are essential for histone H3 methylation and epigenetic control at K4 or K9 and K27, respectively. #
TLE4
(details) 		11840 transducin-like enhancer of split 4 7091 Q04727 TLE4_HUMAN TLE_N PF03920 24-138, WD40 PF00400 480-514 534-561 580-605 610-647 695-728 742-769 Tle4 104633 Q62441 TLE4_MOUSE WDR WD repeat domain containing Histone modification erase cofactor, TF # 24190972 # histone H3ac, H4ac # 24190972 Tle4 is the transcriptional repressor responsible for the establishment of the epigenetic repressive marks at the Ifng locus that result in silencing of Ifng gene expression. Tle proteins have been shown to oligomerize, to associate with amino-terminal domains of histone-modifying proteins, and to form higher-order structures as parts of repressive complexes. #
TLK1
(details) 		11841 tousled-like kinase 1 9874 Q9UKI8 TLK1_HUMAN Pkinase PF00069 458-734 Tlk1 2441683 Q8C0V0 TLK1_MOUSE # # Histone modification write Histone phosphorylation 11314006 # histone H3S10 H3S10ph 11314006 Purified TLK1B phosphorylates histone H3 at S(10) with high specificity both in a mix of core histones and in isolated chromatin, suggesting that histone H3 is a physiological substrate for TLK1B. #
TLK2
(details) 		11842 tousled-like kinase 2 11011 Q86UE8 TLK2_HUMAN Pkinase PF00069 464-741 Tlk2 1346023 O55047 TLK2_MOUSE # # Histone modification write Histone phosphorylation 12660173 # chromatin # # 12660173 There is a functional co-operation between ATM and Chk1 in propagation of a checkpoint response during S phase, suggesting that, through transient inhibition of Tlk kinases, the ATM-Chk1-Tlk pathway may regulate processes involved in chromatin assembly. #
TONSL
(details) 		7801 tonsoku-like, DNA repair protein 4796 Q96HA7 TONSL_HUMAN TPR_8 PF13181 202-235, domain PF13176 311-344, Ank_2 PF12796 529-628, LRR_6 PF13516 1097-1120 1128-1151 1248-1271 Tonsl 1919999 Q6NZL6 TONSL_MOUSE ANKRD Ankyrin repeat domain containing Chromatin remodeling # 21113133 # histone # # 21113133 Mms22L associates with Nfkbil2 =TONSL, which may function as a scaffolding unit to bridge chromatin to multiple protein complexes. #
UHRF1
(details) 		12556 ubiquitin-like with PHD and ring finger domains 1 29128 Q96T88 UHRF1_HUMAN ubiquitin PF00240 2-75, TTD PF12148 133-285, PHD PF00628 318-363, SAD_SRA PF02182 417-585 Uhrf1 1338889 Q8VDF2 UHRF1_MOUSE RNF RING-type (C3HC4) zinc fingers Histone modification read, Histone modification write cofactor Histone ubiquitination 17967883 # histone, DNA H3K9me3, H3R2, H3, mCG H3ub 17967883 ICBP90 =UHRF1and its murine homologue Np95 are enriched in pericentric heterochromatin of interphase nuclei, and this localization is dependent on H3K9 methylation. #
UHRF2
(details) 		12557 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase 115426 Q96PU4 UHRF2_HUMAN ubiquitin PF00240 2-74, TTD PF12148 125-311, PHD PF00628 347-392, SAD_SRA PF02182 445-614 Uhrf2 1923718 Q7TMI3 UHRF2_MOUSE RNF, PHF RING-type (C3HC4) zinc fingers, Zinc fingers, PHD-type Histone modification read # 15361834 # histone, DNA H3K9me3, mCG # 15361834 The SRA domain of the murine homologue of ICBP90=UHRF2, Np95, has histone H3-binding activity (Citterio et al., 2004). Methylated DNA twisted around histone H3 might be the primary target for Np95 and ICBP90 in vivo. #
USP17L2
(details) 		34434 ubiquitin specific peptidase 17-like family member 2 377630 Q6R6M4 U17L2_HUMAN UCH PF00443 81-372 Usp17le 3643640 Q7M764 U17PE_MOUSE # # Histone modification erase cofactor Histone ubiquitination 21239494 # histone # # 21239494 SDS3 is a key component of the histone deacetylase (HDAC)-dependent Sin3A co-repressor complex, serving to maintain its HDAC activity. Both exogenous and endogenous functional interaction between deubiquitinating enzyme USP17 = USP17L2 and human SDS3 has been reported. #
USP44
(details) 		20064 ubiquitin specific peptidase 44 84101 Q9H0E7 UBP44_HUMAN zf-UBP PF02148 28-91, UCH PF00443 273-675 Usp44 3045318 Q8C2S0 UBP44_MOUSE USP Ubiquitin-specific peptidases Histone modification erase Histone ubiquitination 22681888 # histone H2Bub1 H2B 22681888 USP44 is most likely an H2Bub1-specific DUB, whose downregulation during ESC differentiation contributes to increased H2Bub1 levels. #
VIRMA
(details) 		24500 Protein virilizer homolog 25962 Q69YN4 VIR_HUMAN VIR_N PF15912 5-278 Virma 1913435 A2AIV2 VIR_MOUSE ARMH Armadillo like helical domain containing RNA modification RNA methylation 29507755 WMM RNA A of mRNA m6A 29507755 Mediates methylation in 3'UTR and near stop codon New
VPS72
(details) 		11644 vacuolar protein sorting 72 homolog (S. cerevisiae) 6944 Q15906 VPS72_HUMAN YL1 PF05764 7-212, YL1_C PF08265 291-319 Vps72 1202305 Q62481 VPS72_MOUSE # # Histone modification write cofactor Histone acetylation 14966270 NuA4, NuA4-related complex chromatin # # 14966270 The YL1 =VPS72 protein is a subunit of the TRRAP/TIP60 HAT complex. The YL1 protein is also present in cells as a subunit of the previously uncharacterized mammalian SRCAP complex, which bears a striking similarity to the S. cerevisiae SWR1 chromatin remodeling complex. #
WDR5
(details) 		12757 WD repeat domain 5 11091 P61964 WDR5_HUMAN WD40 PF00400 38-72 78-115 119-157 161-199 203-242 246-287 292-331 Wdr5 2155884 P61965 WDR5_MOUSE WDR WD repeat domain containing Histone modification read # 16946699 ATAC, NSL, RING2-L3MBTL2, COMPASS, Menin-associated_HMT, MLL-HCF, CHD8, MLL2/3, COMPASS-like MLL1,2, MLL4/WBP7, COMPASS-like MLL3,4 histone H3K4, H3K4me1, H3K4me2, H3K4me3 # 16946699 The WD40 domain of WDR5 represents a new class of histone methyl-lysine recognition domains that is important for recruiting H3K4 methyltransferases to K4-dimethylated histone H3 tail as well as for global and gene-specific K4 trimethylation. Here is given the crystal structures of full-length WDR5, WDR5Delta23 and its complexes with unmodified, mono-, di- and trimethylated histone H3K4 peptides. #
WHSC1L1
(details) 		12767 Wolf-Hirschhorn syndrome candidate 1-like 1 54904 Q9BZ95 NSD3_HUMAN PWWP PF00855 269-348 962-1050, domain PF23011 700-746, domain PF22908 749-798, domain PF23004 799-851, AWS PF17907 1104-1142, SET PF00856 1155-1262, C5HCH PF17982 1366-1410 Whsc1l1 2142581 Q6P2L6 NSD3_MOUSE # # Chromatin remodeling cofactor, TF # 16682010 # histone H3K4, H3K27 # 16682010 WHISTLE =WHSC1L1 di-methylates H3K4 and di-, and tri-methylates H3K27 of histones. #
WSB2
(details) 		19222 WD repeat and SOCS box containing 2 55884 Q9NYS7 WSB2_HUMAN WD40 PF00400 145-182 188-225 231-267 289-320 338-360, SOCS_box PF07525 367-401 Wsb2 2144041 O54929 WSB2_MOUSE WDR WD repeat domain containing Histone modification write Histone ubiquitination 21070969 # histone # # # May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including histones. (Annotated by similarity). #
ZNHIT1
(details) 		21688 zinc finger, HIT-type containing 1 10467 O43257 ZNHI1_HUMAN zf-HIT PF04438 113-141 Znhit1 1917353 Q8R331 ZNHI1_MOUSE ZNHIT Zinc fingers, HIT-type Chromatin remodeling cofactor, Histone modification erase cofactor Histone acetylation 15647280 SRCAP histone # # 15647280 YL1 protein is also present in cells as a subunit of the previously uncharacterized mammalian SRCAP complex, which bears a striking similarity to the recently described S. cerevisiae SWR1 chromatin remodeling complex and is composed of the SNF2-related SRCAP helicase, ARP6, ZnF/HIT1. #
ZRANB3
(details) 		25249 zinc finger, RAN-binding domain containing 3 84083 Q5FWF4 ZRAB3_HUMAN SNF2-rel_dom PF00176 40-299, Helicase_C PF00271 329-435, zf-RanBP PF00641 623-648, HNH PF01844 1014-1049 Zranb3 1918362 Q6NZP1 ZRAB3_MOUSE ZRANB Zinc fingers, RAN-binding domain containing Chromatin remodeling, Histone modification read cofactor Histone methylation 22705370 # histone # # 22705370 All four proteins (HARP, HARP-like domain (HPL), SMARCA1, RAD54L) belong to the SNF2 =ZRANB3 family, whose members participate in a variety of processes including chromatin remodeling, transcription, DNA repair, and recombination. #